Setd2 (NM_001081340) Mouse Tagged ORF Clone

Specifications

Product Data
Type	Mouse Tagged ORF Clone
Tag	Myc-DDK
Synonyms	4921524K10Rik; BC031601; KMT3A
Vector	pCMV6-Entry
E. coli Selection	Kanamycin (25 ug/mL)
Mammalian Cell Selection	Neomycin
Sequence Data	ORF Nucleotide Sequence (showhide) >MR221649 representing NM_001081340, codon optimized. Due to the complexity of NM_001081340, the ORF clone is codon optimized for mammalian Expression. The nucleotide sequence differs from the reference sequence, yet the amino acid sequence remains identical. Red=Cloning site Blue=ORF Green=Tags(s) TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC GCCGCGATCGCC ATGAAACCCCTCCCCTCCCAGCAGCCTCCTCCAAAGATGGGGGATTTCTACGACCCTGAGCATCCCACCC CTGAGGAGGAGGAGAACGAAGCTAAAATTGAGAACGTACAAAAGACCGGCTTCATAAAAGGGCCTGTATT TAAGGGCGTGGCTTCCAGTCGATTCCTGCCTAAGGGGACGAAGACAAAGGTCAACCTGGAGGAGCAGGGT CGACAAAAAGTGTCCTTTTCTTTCTCATTCACGAAGAAGACCCTGCAAAATCGATTCCTGACGGCCCTGT CCAACGAGAAGCAGTCCGACTCTCCGAACAGTCCCGCACCTCCCCTGCAGGTAGACTCCAACCCAAAAGT CAAGATGGACGCCGGAGATACTTTCCCTGCGACAGAGGAGTCCTCCCCACCTAAATCCCGAGTAGAACTG GGGAGAATCCATTTTAAGAAGCATCTGCTCCATGTAACCAGTCGACCACAGTTGGCCGCCTCCACTACAG CAGCCAGCCCCCTGCCCCCAACCACACAGCTCCCTGCCGTGCTCGCTGAGAGCATGATTGATTCCCCACC ATCCAGTCCACCTCCCCCTCCACCCCCTCCACAGGCCAGTTCACCTAGCCCCCCCGCTCAGATTTCTGAA CCCGTGGCCCTTCCGCAGCCTCCTGCCACCGCTCTGATGACATCCCCTCCTGGACCACTGCCCGGTGATG TCGCTGTGCGAGCCCAAAAGGAGAGTCCAGTTAAGAGCGGCCCCGAAGTCCTCGAAGTCGACACTAAACA AGATATTGTGAGTAATTCTCTTGAGGAACATACGGTGCAGACCCTTAAGGAACAAGCCGATCATCTGCTC CAGAAAGAGGACTCACACATCGGAAAAGAAGAGGAGGTGAGCGACGGCTCCAAGATCTCCCTGAGCTCAA AAAAAGCTTCAAGCAAGAAGAAAAGCTCCCAATTTGAAGGGACATTCCTCGGTTCTGAGAGCGACGAGGA CAGCGTTAGAACTTCTTCCTCCCAGCGAAGTCATGACCTCAAGTCCAGTACCAGCATCGACAAGGAAAGA GATTTCAAGAAGAGCAGTGCCCCCTCAAAATCTGAAGACCTCGGAAAGTCATCCAGGTCTAAGACCGAGC GCGATGACCGATATTGCTCATATAGTAAGCTGGAACGCGATACTCGCTACGTTTCTTCCAGGTGTAGATC CGAGCGGGACCGAAGAAGATCCCGCTCTCGCTCACGGTCCGACCGGGCAAGCCGAACCAGTCTGTCATAT AGTCGCTCCGAGAGATCCCATTATTATGACTCCGAAAGGCGCTACCACCGCAGTTCCCCTTACAGAGAAA GAACTAGATATTCAAGGCCTTATACGGACAATCGGGCCCGCGAATCTTCAGATTCCGAGGATGAATACAA GAAAACATACCCACGGAGAACATCAGCCCACAGCTACAGAGACTTGAGGACTTCTTCAAGCTACTCCAAG TTCGACAGAGATTGCAAGACAGAAACATCCTACCTTGAGATGGAGCGGCGAGGCAAGTATACTAGTAAAC TTGAGAGAGAGTCCAAACGAACAAGCGAACACGAGACGATCAAGCGATGCTGCTCACCCCCAAACGAGCT GGGCTTTCGGCGAGGCAGCTCCTATAGTAAACATGACAATTCCACCAGCAGATACAAGTCCGCCCTGTCA AAGAGCATATCTAAAAACGATAAATTCAAAAACTCCTTCTGCTGTACCGAACTGAACGAGGAAAACAAAC AGTCACACAGCTTCAGTCTTCAAACCCCCTGCTCCAAGGGCAGCGAGCTGAGGACCATTAACAAGATCAG TGAGAGAGAGAAAACAGGATCCCCGACCCCAAGTAACCAGCTTAACGATTCCCCCACTTTTAAGAAACTG GATGAGTCTCCTGTGCTGAAACCAGAGTTTATCGGCCATGACGGGCGCGAGAGCATTAAGGAACTTGAAC TGTCTAAGGTAAAAAACGACCAGCTCCGCAATTTTTGCAGCATCGAGCTGAACGTAAACGGATCTCCAGA AACTGAAGCCGATGTGGCTACATTCTGCACAAGCAAGACAGATGCCATTAGTATGACATCCGACGACAGT GTGACCGGCTCAGAGGTGTCCCCCTTGATCAAAGCATGCATGCTGAGCAGCAATGGGTTTCAGAACGTCG GTCGGTGTCGGGAGCGCGATTCAGACGATACGTGCCGCCAGCATAATACCAGCAAGTCTCCTTTCAGAGA AATGGAGCCACTGCTGAGCCCTCACCACGATAAGCTGATGAGCTTGCCAGTCAAGACAATTGACTACCCT AAGACATTGATTAAGGAACCGGTGGACAAGAGACACTCTTGCTGCAAAACTAAGGATAGCGATATCTACT GTTCCCCTAATGAAAATCCAGAGGCAGAAAACGCCGAGCCTTCTGCTATGACTATCAGCTCTCATTCTTT CGTCAACGTGCATTTGGAAAGTAAAACCGTAATATGCGACAACCGAGAGCCCACCGATCGACATAGCGAA AATACTTGTGATGAGTACAAACAGAGTATCGGCAGCACCTCCTCCGCGAGCCATAATCATTTCGACGGCC TGTACGAGCCCATCGGATCTAGTGGGATCAGCTCCCTGCAGAGCCCACCCTCTGGGATCCGCTGCGAGGA GAACACCAGTCCAACTTTGGACGCTGTCGAGAGTAAGAAAGGCATCGATTTCCTGAAGTACGCTCGCAAA GAAACCGACGTGGGAAGTGCCCTGCCAGATAGTGGCAAGGGGTTTTCTTGGGAAAATAGGCATAACAATG TGCTGAGTGGCCAGTCCTTGCAGGAGGCACAGGAGGAAGGAAATTCAATTCTTCATGAGCGGCGCGGAAG GCCCGAGATTCCCCTTGACGAGGAGCAGCGCGGCCATACACACATCAGTGACGATTCTGAGGTGGTGTTT CCGTACGACCTCAACCTTACCATGGAGGACTCTGACGGCATTACGTACACGCTGAAGTGTGACTCCTCAG GTAACGCACCTGAAATTGTCAGTACTGTACACGAAGACTACAGTGGGTCCTCTGCCTCCTCCTCCGACGA GAGCGACTCCGAGGACACTGAAAGTGACGATAGCAGTATTCCAAGAAACCGACTCCAGTCTGTTGTGGTT GTGCCAAAGAATTCTACTTTGCCCATGGAAGAGACAAGTCCCTGTTCTTCTCGGAGCAGTCAGAGCTACA AACATTATTCTGACCGCTGGGAAGATGGATTAGAGACCAGGAGACATGCATATGAGGAAGAGTATGAGAG TAAAGGCTGTTCTCAAACTGAAAAATACTTCCTTCATAAAGGAACAGAGAGAAGTGCAGAAAGTTGTTAT TCACAGTTTGGCAGGAAAGCAGATAATCACCTGCCTGACATTGCTCATGCTCAGAGTGACGGGGTTGATA GTACAAGTCAGACAGACTCGAGATCTGACCATCTAGGTCACCTGAATCCAGAGGACACATTAAGAGCCAA AACATCTAGGCCACAAGAGCTACCAGTTTATTCTGACGATTTTGAAGATCTCCCAAATAAGTCTCGGCAG CAGATGATTTTCTCTAATCGGCCAGATAGTAGTAGACTAGGAAAAACAGAGCTGAGTTTTTCTTCCTCTT GTGACATTTCCCGAATGGATGGCTTGCACTCATCAGAAGAGCTCAGAAACCTAGGGTGGGACTTTTCCCA ACAGGAAAGGCCCACCACCACATACCAGCAGCCTGACAGCAGCTATGGAACCTGTGGTACACATAAGTAT CAACAAAGTACTGAACACTATGGTGGGACCCATAATTACTGGCAAGGCAATGGCTATTGGGATCCAAGAT CAGCAGGTAGACCTCCAGGAACTGGGCTTGCTTATGATCGAATCCAAGGGCAAGTACCAGATTCTCTAAC AGACGATCGTGAAGAAGAGGAACATTGGGATCAACGAAGTGGATCACATTTTTCAAGCCCGTCCAATAAA TTTTTCTTCCATCAGAAGGACAAGGGATCAGTGCAAGCACCGGAAATAAGCAGCAATTCAATTAAAGACG CTTTAGTTATGAACGAAAGGAAAGATTTTTCGAAAAACTTTGAAAAAAATGATATAAAAGAGAGAGGGCC TCCTAAAAAACGAAGGCAAGAGTTGGAGAGTGATTCTGAAAGTGATGGTGAACTACAGGCTAGAAAGAAA GTTAGAGTGGAGATGGAGCAGGGAGAATCATCTGTGCCCCAGCACTCAGAACTGATGGGGCCTTCGTGTG CTATGGATGACTTCAGGGACCCACAGCGGTGGAAAGAATTTGCCAAGCTGGGGAAGATGCCATGTTACTT TGATCTTATTGAAGAAAATGTTTATTTAACAGAAAGGAAGAAGAACAAATCCCACCGGGATATTAAGCGA ATGCAGTGTGAGTGTACACCTCTTTCTAAGGATGAAAGAGCTCAAGGTGAAGTAGCATGTGGAGAAGATT GCCTTAATCGTCTCCTCATGATTGAATGTTCCTCTCGATGTCCAAATGGAGATTACTGTTCAAACAGACG GTTTCAGAGAAAACAGCATGCAGATGTAGAAGTCATACTTACAGAAAAGAAAGGCTGGGGCTTAAGGGCT GCTAAGGATCTTCCTTCGAACACCTTTGTCCTGGAATACTGTGGAGAGGTACTTGATCATAAAGAGTTTA AAGCTCGGGTGAAAGAATATGCACGGAACAAAAACATCCACTACTACTTCATGGCCCTGAAAAATGACGA GATAATAGATGCCACTCAAAAAGGGAATTGCTCTCGTTTCATGAATCATAGCTGTGAACCAAACTGTGAA ACCCAGAAATGGACTGTGAATGGACAGCTGAGGGTTGGATTTTTTACCACCAAACTAGTTCCTTCAGGCT CAGAATTAACTTTTGACTACCAGTTCCAAAGATATGGCAAAGAAGCTCAGAAGTGTTTCTGTGGGTCAGC CAACTGCCGGGGCTACTTGGGAGGAGAAAACAGAGTCAGTATCAGAGCTGCAGGAGGGAAGATGAAAAAG GAACGCTCTCGAAAGAAGGATTCAGTGGATGGAGAACTTGAAGCACTGATGGAAAATGGTGAAGGCCTCT CTGATAAGAACCAGGTTCTTAGTTTATCCCGGCTCATGGTTAGAATTGAAACTTTGGAACAGAAACTTAC CTGTCTTAAGCTCATTCAGAACACACACTCACAGTCCTGCCTCAAGTCATTTCTGGAACGTCATGGGTTG TCACTGTTGTGGATCTGGATGGCAGAGCTTGGCGACGGCCGGGAAAGTAACCAGAAGCTTCAGGAAGAGA TTATAAAGACTTTGGAGCATTTGCCCATTCCTACTAAAAATATGTTGGAAGAAAGCAAAGTACTTCCAAT TATTCAGCGCTGGTCTCAAACTAAGACTGCTGTTCCTCAGTTAAGTGAAGGAGACGGGTATTCTAGTGAG AATACATCACGTGCTCACACACCGCTTAATACACCGGACCCTTCTGCCAAGCCGAGCACGGAAATGGATA CAGATACTCCCAAGAAACTCATATTCCGCAGACTGAAGATTATAAGTGAAAATAGCATGGACAGTGCAGT CTCGGACGTCACTAGTGAGCTAGAATGCAAGGATGGCAAAGAGGACCTTGATCAGTTAGAGACTGTCACT GTGGAAGAGGATGAAGAGCTGCAGTCCCAGCAGCTCCTCCCACAGCAGCTGTGCGAGTCCAAAGTTGAGA GTGAAGCCACTATTGAAGTCAGTAAGTTACCCACATCTGAACCGGAGGCAGACACGGAGACAGAGCCCAA AGACAGCAATGGCACAAAACTAGAAGAAACTATTGCTGAGGAAACACCATCCCAAGATGAAGAAGAGGGA GTGTCTGATGTTGAAAGTGAGAGAAGCCAGGAGCCACCAGATAAAACAGTGGATATAAGTGATTTGGCTA CCAAGTTACTAGACAGTTGGAAAGATCTAAAGGAGGTGTATCGGATTCCAAAGAAAAGTCAAACTGAAAA GGAGAGCACAGTAGCTGAACGAGGAAGAGATGCTGCTGCCTTCAGAGATCAAACAGCTCCAAAGACTCCT AACAGGTCTAGAGAGAGAGACCCAGACAAGCAGTCTCAAAATAAAGAGAAAAGGAAACGACGGGGCTCTC TGTCACCACCCTCTTCTGCATATGAGCGGGGAACAAAAAGGCCAGATGACAGATATGATACACCAACTTC TAAAAAGAAAGTACGAATTAAAGACCGAAACAAACTTTCTACAGAGGAGCGCAGGAAGTTGTTTGAACAA GAGGTGGCACAGAGGGAAGCTCAGAAGCAACAGCAACAGATGCAGAACTTGGGGATGACATCACCACTCC CCTTTGACTCTCTGGGATATAATGCCTCTCATCACCCCTTTGCTGGGTACCCACCAGGTTACCCCATGCA AGCCTATGTGGATCCCAGCAACCCTAATGCTGGAAAGGTGCTTCTGCCCACACCTAGCATGGACCCTGTG TGCTCCCCTGCTCCTTATGATCACGCTCAGCCCTTGGTAGGACATTCTACAGAATCCCTTGCTGCTCCCC CATCTGTGCCAGTGGTGCCGCATGTGGCAGCCTCTGTGGAAGTTTCCAGTTCTCAGTATGTAGCTCAGAA TGAAAGTGTTGTACACCAAGACTCCAATGTTCCTGTAATGCCAGTACAAGCTCCAGGCCCAGTCCAAGGA CAGAATTACAATGTCTGGGAGTCAAACCAACAGTCTGTCAGTGTACAACAGCAGTATTCTCCTGCACAAT CTCAAACAACCATATATTATCAAGGACAGACATGTTCAACTGTCTATAGTGTGACCTCGCCTTATTCACA GACAACTCCTCCAATTGTGCAGAGTTATGCCCAGCCAAGTCTTCAGTATATCCAGGGACAGCAGATTTTC ACAGCTCACCCACAAGGAGTGGTGGTACAGCCAACTGCAGCCGTGACTTCAATAGTTGCACCAGGGCAGC CTCAGTCCTTACAGCCACCTGAAATGGTTGTAACAAATAATCTACTGGACCTGCCACCACCCTCCCCTCC AAAACCAAAAACGATTGTTTTACCTCCCAACTGGAAGACAGCCCGAGACCCTGAGGGGAAGATCTACTAC TACCACGTGATCACAAGACAGACTCAGTGGGATCCTCCTACTTGGGAAAGCCCAGGAGATGATGCCAGCC TTGAGCATGAAGCTGAAATGGACCTGGGAACCCCAACCTATGATGAAAACCCCATGAAGACATCAAAAAA GCCCAAGACAGCAGAAGCAGACACCTCCAGTGAGCTGGCAAAGAAAAGCAAAGAAGTATTCAGAAAAGAG ATGTCTCAGTTCATTGTCCAGTGCCTGAATCCTTACCGGAAACCTGACTGCAAGGTGGGCAGGATCACCA CCACTGAAGATTTCAAGCACCTCGCCCGAAAGCTGACTCATGGAGTTATGAATAAGGAGCTGAAGTACTG TAAGAACCCCGAGGACCTGGAGTGCAATGAGAATGTGAAACACAAAACCAAGGAGTACATCAAGAAGTAC ATGCAGAAGTTTGGGGCTGTTTACAAACCTAAAGAGGACACTGAACTAGAG ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT ACAAGGATGACGACGATAAGGTTTAA Protein Sequence (showhide) >MR221649 representing NM_001081340 Red=Cloning site Green=Tags(s) MKPLPSQQPPPKMGDFYDPEHPTPEEEENEAKIENVQKTGFIKGPVFKGVASSRFLPKGTKTKVNLEEQG RQKVSFSFSFTKKTLQNRFLTALSNEKQSDSPNSPAPPLQVDSNPKVKMDAGDTFPATEESSPPKSRVEL GRIHFKKHLLHVTSRPQLAASTTAASPLPPTTQLPAVLAESMIDSPPSSPPPPPPPPQASSPSPPAQISE PVALPQPPATALMTSPPGPLPGDVAVRAQKESPVKSGPEVLEVDTKQDIVSNSLEEHTVQTLKEQADHLL QKEDSHIGKEEEVSDGSKISLSSKKASSKKKSSQFEGTFLGSESDEDSVRTSSSQRSHDLKSSTSIDKER DFKKSSAPSKSEDLGKSSRSKTERDDRYCSYSKLERDTRYVSSRCRSERDRRRSRSRSRSDRASRTSLSY SRSERSHYYDSERRYHRSSPYRERTRYSRPYTDNRARESSDSEDEYKKTYPRRTSAHSYRDLRTSSSYSK FDRDCKTETSYLEMERRGKYTSKLERESKRTSEHETIKRCCSPPNELGFRRGSSYSKHDNSTSRYKSALS KSISKNDKFKNSFCCTELNEENKQSHSFSLQTPCSKGSELRTINKISEREKTGSPTPSNQLNDSPTFKKL DESPVLKPEFIGHDGRESIKELELSKVKNDQLRNFCSIELNVNGSPETEADVATFCTSKTDAISMTSDDS VTGSEVSPLIKACMLSSNGFQNVGRCRERDSDDTCRQHNTSKSPFREMEPLLSPHHDKLMSLPVKTIDYP KTLIKEPVDKRHSCCKTKDSDIYCSPNENPEAENAEPSAMTISSHSFVNVHLESKTVICDNREPTDRHSE NTCDEYKQSIGSTSSASHNHFDGLYEPIGSSGISSLQSPPSGIRCEENTSPTLDAVESKKGIDFLKYARK ETDVGSALPDSGKGFSWENRHNNVLSGQSLQEAQEEGNSILHERRGRPEIPLDEEQRGHTHISDDSEVVF PYDLNLTMEDSDGITYTLKCDSSGNAPEIVSTVHEDYSGSSASSSDESDSEDTESDDSSIPRNRLQSVVV VPKNSTLPMEETSPCSSRSSQSYKHYSDRWEDGLETRRHAYEEEYESKGCSQTEKYFLHKGTERSAESCY SQFGRKADNHLPDIAHAQSDGVDSTSQTDSRSDHLGHLNPEDTLRAKTSRPQELPVYSDDFEDLPNKSRQ QMIFSNRPDSSRLGKTELSFSSSCDISRMDGLHSSEELRNLGWDFSQQERPTTTYQQPDSSYGTCGTHKY QQSTEHYGGTHNYWQGNGYWDPRSAGRPPGTGLAYDRIQGQVPDSLTDDREEEEHWDQRSGSHFSSPSNK FFFHQKDKGSVQAPEISSNSIKDALVMNERKDFSKNFEKNDIKERGPPKKRRQELESDSESDGELQARKK VRVEMEQGESSVPQHSELMGPSCAMDDFRDPQRWKEFAKLGKMPCYFDLIEENVYLTERKKNKSHRDIKR MQCECTPLSKDERAQGEVACGEDCLNRLLMIECSSRCPNGDYCSNRRFQRKQHADVEVILTEKKGWGLRA AKDLPSNTFVLEYCGEVLDHKEFKARVKEYARNKNIHYYFMALKNDEIIDATQKGNCSRFMNHSCEPNCE TQKWTVNGQLRVGFFTTKLVPSGSELTFDYQFQRYGKEAQKCFCGSANCRGYLGGENRVSIRAAGGKMKK ERSRKKDSVDGELEALMENGEGLSDKNQVLSLSRLMVRIETLEQKLTCLKLIQNTHSQSCLKSFLERHGL SLLWIWMAELGDGRESNQKLQEEIIKTLEHLPIPTKNMLEESKVLPIIQRWSQTKTAVPQLSEGDGYSSE NTSRAHTPLNTPDPSAKPSTEMDTDTPKKLIFRRLKIISENSMDSAVSDVTSELECKDGKEDLDQLETVT VEEDEELQSQQLLPQQLCESKVESEATIEVSKLPTSEPEADTETEPKDSNGTKLEETIAEETPSQDEEEG VSDVESERSQEPPDKTVDISDLATKLLDSWKDLKEVYRIPKKSQTEKESTVAERGRDAAAFRDQTAPKTP NRSRERDPDKQSQNKEKRKRRGSLSPPSSAYERGTKRPDDRYDTPTSKKKVRIKDRNKLSTEERRKLFEQ EVAQREAQKQQQQMQNLGMTSPLPFDSLGYNASHHPFAGYPPGYPMQAYVDPSNPNAGKVLLPTPSMDPV CSPAPYDHAQPLVGHSTESLAAPPSVPVVPHVAASVEVSSSQYVAQNESVVHQDSNVPVMPVQAPGPVQG QNYNVWESNQQSVSVQQQYSPAQSQTTIYYQGQTCSTVYSVTSPYSQTTPPIVQSYAQPSLQYIQGQQIF TAHPQGVVVQPTAAVTSIVAPGQPQSLQPPEMVVTNNLLDLPPPSPPKPKTIVLPPNWKTARDPEGKIYY YHVITRQTQWDPPTWESPGDDASLEHEAEMDLGTPTYDENPMKTSKKPKTAEADTSSELAKKSKEVFRKE MSQFIVQCLNPYRKPDCKVGRITTTEDFKHLARKLTHGVMNKELKYCKNPEDLECNENVKHKTKEYIKKY MQKFGAVYKPKEDTELE TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Restriction Sites	SgfI-MluI      Cloning Scheme for this gene      Plasmid Map
ACCN	NM_001081340
ORF Size	7611 bp
OTI Disclaimer	The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
OTI Annotation	This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
Product Components	The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution	1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq	NM_001081340.2, NP_001074809.2
RefSeq Size	8350 bp
RefSeq ORF	7614 bp
Locus ID	235626
UniProt ID	E9Q5F9
MW	285.7 kDa
Gene Summary	Histone methyltransferase that specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using dimethylated 'Lys-36' (H3K36me2) as substrate (PubMed:18157086, PubMed:20133625). Represents the main enzyme generating H3K36me3, a specific tag for epigenetic transcriptional activation (PubMed:18157086, PubMed:20133625). Plays a role in chromatin structure modulation during elongation by coordinating recruitment of the FACT complex and by interacting with hyperphosphorylated POLR2A (By similarity). Acts as a key regulator of DNA mismatch repair in G1 and early S phase by generating H3K36me3, a mark required to recruit MSH6 subunit of the MutS alpha complex: early recruitment of the MutS alpha complex to chromatin to be replicated allows a quick identification of mismatch DNA to initiate the mismatch repair reaction (By similarity). Required for DNA double-strand break repair in response to DNA damage: acts by mediating formation of H3K36me3, promoting recruitment of RAD51 and DNA repair via homologous recombination (HR) (By similarity). Acts as a tumor suppressor (By similarity). H3K36me3 also plays an essential role in the maintenance of a heterochromatic state, by recruiting DNA methyltransferase DNMT3A (By similarity). H3K36me3 is also enhanced in intron-containing genes, suggesting that SETD2 recruitment is enhanced by splicing and that splicing is coupled to recruitment of elongating RNA polymerase (By similarity). Required during angiogenesis (PubMed:20133625). Required for endoderm development by promoting embryonic stem cell differentiation toward endoderm: acts by mediating formation of H3K36me3 in distal promoter regions of FGFR3, leading to regulate transcription initiation of FGFR3 (PubMed:25242323). In addition to histones, also mediates methylation of other proteins, such as tubulins and STAT1 (PubMed:27518565). Trimethylates 'Lys-40' of alpha-tubulins such as TUBA1B (alpha-TubK40me3); alpha-TubK40me3 is required for normal mitosis and cytokinesis and may be a specific tag in cytoskeletal remodeling (PubMed:27518565). Involved in interferon-alpha-induced antiviral defense by mediating both monomethylation of STAT1 at 'Lys-525' and catalyzing H3K36me3 on promoters of some interferon-stimulated genes (ISGs) to activate gene transcription (By similarity).[UniProtKB/Swiss-Prot Function]

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.