Naip5 (NM_010870) Mouse Untagged Clone
CAT＃: MC224389
Naip5 (untagged) - Mouse NLR family, apoptosis inhibitory protein 5 (Naip5), (10ug)
CNY 18050.00
货期*
8周
规格
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Specifications
| Product Data | |
| Type | Mouse Untagged Clone |
| Tag | Tag Free |
| Synonyms | Birc1e; Lgn1; Naip-rs3 |
| Vector | pCMV6-Entry |
| E. coli Selection | Kanamycin (25 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data |
>MC224389 representing NM_010870
Red=Cloning site Blue=ORF Orange=Stop codon TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC GCCGCGATCGCC ATGGCTGAGCATGGGGAGTCCTCCGAGGATCGGATTTCTGAGATTGATTATGAATTTCTCCCCGAGCTCT CTGCTCTTCTCGGGGTGGATGCATTTCAGGTGGCAAAGAGCCAAGAAGAAGAAGAGCATAAAGAACGGAT GAAAATGAAGAAAGGTTTTAACTCACAGATGCGCAGTGAAGCCAAACGACTAAAGACCTTTGAGACCTAT GACACGTTCAGATCATGGACGCCACAGGAGATGGCAGCTGCTGGGTTTTACCACACAGGGGTGAGACTTG GCGTTCAGTGCTTTTGCTGTAGCTTGATCCTCTTTGGTAACAGCCTCAGGAAGCTTCCCATAGAGAGACA CAAGAAATTACGTCCGGAATGTGAGTTCCTTCAGGGCAAAGATGTTGGTAACATTGGCAAGTATGACATC CGGGTGAAGAGGCCAGAGAAGATGCTGAGAGGTGGCAAAGCCAGGTACCATGAAGAGGAGGCCAGACTGG AGTCCTTTGAGGACTGGCCATTTTATGCCCATGGGACATCACCACGTGTACTCTCAGCAGCTGGCTTTGT CTTTACAGGTAAAAGGGACACTGTGCAGTGTTTCTCCTGTGGCGGAAGCTTGGGCAACTGGGAAGAAGGA GATGACCCCTGGAAGGAGCATGCCAAGTGGTTCCCCAAATGTGAATTTCTTCAAAGTAAGAAATCCTCAG AGGAAATTGCCCAGTATATTCAAAGCTACGAGGGATTTGTTCATGTAACGGGAGAACATTTTGTGAAGTC CTGGGTCAGAAGAGAATTACCTATGGTATCAGCTTACTGCAATGACAGTGTCTTCGCTAATGAAGAACTA AGGATGGACATGTTTAAGGACTGGCCCCAAGAATCACCTGTGGGTGTTGAAGCTCTAGTCAGAGCAGGCT TTTTCTACACTGGCAAAAAGGACATTGTCCGGTGTTTTTCCTGTGGAGGATGTTTGGAAAAGTGGGCAGA AGGTGACGACCCAATGGAAGATCACATCAAGTTTTTTCCCGAATGTGTATTTCTTCAAACCTTGAAGTCC TCTGCAGAAGTAATTCCAACCCTTCAGAGCCAATATGCACTTCCAGAAGCCACGGAAACCACACGTGAAA GCAACCATGGTGATGCAGCAGCAGTTCATTCTACAGTGGTGGACTTGGGTAGGAGTGAAGCCCAGTGGTT TCAAGAGGCCAGGAGTCTGAGTGAGCAGCTAAGAGACAACTACACTAAAGCCACTTTCCGCCACATGAAC TTGCCAGAAGTGTGCTCCAGCCTTGGCACTGACCACTTGCTCAGCTGCGATGTGTCCATCATTTCAAAGC ACATCAGCCAGCCTGTGCAAGAGGCCCTGACGATCCCCGAGGTCTTCTCCAATCTCAACTCTGTCATGTG TGTGGAGGGGGAAACTGGCAGTGGAAAGACAACCTTCCTGAAGAGGATAGCTTTTCTCTGGGCATCAGGA TGCTGCCCCCTGTTGTACAGGTTCCAGCTGGTCTTCTATCTCTCCCTTAGTTCCATCACACCAGATCAGG GACTGGCCAACATCATCTGTGCCCAACTCCTAGGGGCAGGAGGTTGCATTAGTGAAGTGTGTCTGAGCAG CAGCATCCAGCAGTTACAACACCAGGTGCTGTTCCTGTTGGATGACTACAGTGGGCTGGCCTCACTCCCC CAAGCCCTACACACACTGATTACAAAAAACTACTTGTCACGGACCTGCTTATTGATCGCTGTGCATACAA ACAGGGTCAGAGACATCCGCCTATACCTAGGTACAAGTCTAGAGATCCAAGAGTTTCCCTTCTATAATAC TGTCTCTGTATTACGGAAGTTTTTTTCACATGACATAATCTGTGTGGAAAAGCTTATAATTTACTTTATT GATAATAAAGATTTACAGGGAGTTTACAAGACCCCTCTCTTTGTAGCAGCAGTATGTACTGACTGGATTC AAAATGCATCTGCCCAGGATAAATTTCAAGATGTGACACTTTTCCAGTCCTACATGCAATACCTGTCCTT AAAATACAAAGCTACAGCTGAGCCTCTCCAGGCCACTGTGTCCTCATGTGGGCAGCTGGCCTTGACAGGG CTTTTCTCATCATGCTTTGAGTTCAATAGTGATGACCTGGCAGAGGCAGGAGTTGATGAAGATGAAAAGC TTACCACCCTCTTGATGAGCAAATTCACCGCCCAGAGACTGAGACCAGTCTACCGGTTTTTAGGTCCTCT GTTCCAGGAGTTTCTTGCTGCCGTGAGGTTGACTGAACTCCTGAGTTCAGATAGGCAGGAAGACCAAGAT CTTGGACTTTATTATTTGAGACAAATCGACTCACCTCTGAAGGCAATAAACTCCTTTAACATATTTTTGT ATTATGTCTCCAGCCACTCTTCCTCAAAGGCAGCGCCAACAGTTGTATCTCATTTGCTTCAGTTGGTGGA TGAGAAAGAGTCACTGGAGAACATGTCTGAAAATGAGGATTACATGAAGCTCCATCCACAAACTTTTCTA TGGTTTCAGTTTGTTAGAGGGTTGTGGCTGGTGTCTCCTGAATCTTCCTCTTCATTCGTTTCAGAACATT TATTGCGCCTTGCTCTAATCTTTGCTTATGAAAGCAACACAGTTGCTGAATGCTCTCCATTTATTTTGCA ATTCCTTCGAGGAAAAACACTGGCTTTAAGAGTACTGAATTTACAGTACTTTAGGGACCACCCAGAAAGC CTGTTACTGTTGAGGAGCTTAAAGGTTTCCATAAATGGAAATAAAATGTCATCTTATGTAGATTATTCAT TCAAGACATATTTTGAAAACTTACAGCCACCAGCTATAGATGAGGAGTATACATCTGCCTTTGAGCATAT AAGTGAATGGAGGAGAAATTTTGCTCAAGATGAGGAGATCATAAAAAACTATGAAAATATCCGACCCAGA GCCCTACCAGACATCAGTGAAGGGTACTGGAAACTGTCCCCCAAGCCATGCAAGATCCCCAAGCTGGAAG TTCAAGTGAACAACACGGATGCAGCAGATCAAGCACTGCTCCAGGTCCTCATGGAAGTCTTCTCAGCTTC ACAGAGTATTGAGTTCCGTTTATTCAACAGCAGTGGCTTCCTTGAAAGCATCTGCCCAGCTCTGGAGCTG AGTAAGGCCTCTGTCACCAAGTGTTCCATGTCCAGGCTGGAGCTCAGCAGAGCAGAACAGGAGCTGCTTC TCACCCTGCCTGCCCTGCAGTCTCTCGAGGTCTCAGAGACAAACCAGTTACCAGAACAGCTCTTCCATAA CTTGCACAAGTTCCTGGGCCTGAAAGAACTGTGTGTGAGACTAGATGGCAAACCGAATGTGCTCTCAGTC CTTCCTAGAGAGTTCCCAAACCTCCTTCACATGGAGAAGTTATCCATCCAAACCTCCACGGAGTCTGACC TCTCCAAACTAGTTAAATTCATCCAGAACTTTCCAAATCTCCATGTTTTCCATCTGAAATGTGATTTCCT TTCAAATTGTGAGTCTCTCATGGCTGTGCTTGCTTCCTGCAAGAAACTCAGAGAGATTGAGTTTTCTGGA CGATGCTTTGAAGCCATGACCTTTGTCAACATTTTGCCAAATTTTGTTTCTCTGAAGATACTGAATCTTA AAGATCAACAATTTCCAGATAAGGAAACGTCAGAAAAGTTTGCCCAGGCTCTGGGTTCTCTCAGGAACCT GGAGGAACTGCTCGTTCCCACTGGGGACGGGATTCACCAAGTGGCCAAACTGATTGTCCGGCAGTGTCTG CAGCTTCCGTGCCTCCGAGTTCTCACCTTTCACGACATCTTGGACGATGACAGTGTGATTGAAATTGCCA GGGCGGCAACCAGTGGAGGTTTCCAGAAACTTGAGAACTTAGATATTTCCATGAATCACAAGATTACCGA GGAAGGATATAGAAATTTCTTTCAAGCCCTGGACAACTTGCCAAACCTACAAGAGCTGAACATCTGCAGG AATATCCCAGGACGCATTCAAGTTCAGGCCACCACTGTCAAGGCTCTGGGTCAATGTGTGTCCCGACTGC CCAGCCTCATCAGACTGCACATGCTCAGTTGGCTCCTGGATGAAGAGGACATGAAAGTGATTAATGATGT GAAGGAAAGACATCCCCAGTCTAAACGCTTGATTATCTTCTGGAAATTGATAGTCCCATTCTCTCCTGTT ATCCTGGAGTAA ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT ACAAGGATGACGACGATAAGGTTTAA |
| Restriction Sites | SgfI-MluI |
| ACCN | NM_010870 |
| Insert Size | 4212 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_010870.2, NP_035000.2 |
| RefSeq Size | 5368 bp |
| RefSeq ORF | 4212 bp |
| Locus ID | 17951 |
| UniProt ID | Q9R016 |
| Gene Summary | Sensor component of the NLRC4 inflammasome that specifically recognizes and binds flagellin from pathogenic bacteria such as Legionella or Salmonella (PubMed:12526741, PubMed:21874021, PubMed:21918512, PubMed:29146805, PubMed:29182158). Association of pathogenic bacteria proteins drives in turn drive assembly and activation of the NLRC4 inflammasome, promoting caspase-1 activation, cytokine production and macrophage pyroptosis (PubMed:21874021, PubMed:21918512, PubMed:29146805, PubMed:29182158). The NLRC4 inflammasome is activated as part of the innate immune response to a range of intracellular bacteria. The NLRC4 inflammasome senses Gram-negative bacteria such as L.pneumophila and P.aeruginosa, enteric pathogens S.typhimurium (Salmonella) and S.flexneri (PubMed:21874021, PubMed:21918512, PubMed:29146805, PubMed:29182158). May contribute to prevent motor-neuron apoptosis induced by a variety of signals (By similarity).[UniProtKB/Swiss-Prot Function] |
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| MR211969 | Naip5 (Myc-DDK-tagged) - Mouse NLR family, apoptosis inhibitory protein 5 (Naip5) |
CNY 9600.00 |
|
| MR211969L3 | Lenti ORF clone of Naip5 (Myc-DDK-tagged) - Mouse NLR family, apoptosis inhibitory protein 5 (Naip5) |
CNY 12730.00 |
|
| MR211969L4 | Lenti ORF clone of Naip5 (mGFP-tagged) - Mouse NLR family, apoptosis inhibitory protein 5 (Naip5) |
CNY 12730.00 |
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