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Insr (NM_010568) Mouse Untagged Clone
CAT＃: MC224356
Insr (untagged) - Mouse insulin receptor (Insr), (10ug)
CNY 14,088.00
货期*
现货
规格
| Cited in 4 publications. |
Product images
经常一起买 (3)
Specifications
| Product Data | |
| Type | Mouse Untagged Clone |
| Tag | Tag Free |
| Synonyms | 4932439J01Rik; CD220; D630014A15Rik; I; IR; IR-A; IR-B |
| Vector | pCMV6-Entry |
| E. coli Selection | Kanamycin (25 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data |
>MC224356 representing NM_010568
Red=Cloning site Blue=ORF Orange=Stop codon TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC GCCGCGATCGCC ATGGGCTTCGGGAGAGGATGTGAGACGACGGCTGTGCCATTGCTGGTGGCCGTGGCCGCGTTGCTGGTGG GCACAGCCGGCCACCTGTACCCTGGAGAGGTGTGCCCTGGTATGGACATCCGGAACAACCTGACCAGGCT ACATGAGCTGGAGAACTGCTCAGTCATTGAGGGCCATCTGCAGATCCTCCTGATGTTCAAGACCAGACCC GAAGATTTCCGAGACCTCAGTTTCCCCAAACTCATCATGATCACAGATTACCTGCTTCTCTTCCGTGTCT ATGGTCTGGAAAGTCTGAAAGACCTCTTCCCAAATCTCACAGTCATCCGAGGCTCCCGTCTCTTCTTCAA CTATGCCCTGGTTATCTTCGAGATGGTCCACCTGAAGGAGCTGGGGCTTTATAACCTCATGAACATCACC CGGGGCTCTGTCCGCATCGAGAAGAATAATGAGCTCTGCTACCTGGCCACTATCGACTGGTCCCGTATCC TGGATTCTGTGGAGGACAACTACATTGTACTGAACAAAGATGACAACGAGGAATGTGGGGATGTCTGTCC AGGCACCGCCAAGGGCAAGACCAACTGTCCTGCCACTGTCATCAATGGGCAGTTTGTGGAACGGTGCTGG ACACACAGTCATTGTCAGAAAGTTTGCCCAACCATCTGTAAGTCACATGGCTGCACAGCTGAAGGCCTGT GCTGCCACAAAGAGTGCCTGGGCAACTGTTCGGAACCTGATGACCCCACCAAGTGTGTGGCCTGTCGCAA CTTCTATCTGGATGGTCAGTGTGTGGAGACCTGCCCGCCACCCTACTATCACTTCCAGGACTGGCGCTGT GTGAACTTCAGCTTCTGCCAAGACCTTCACTTCAAATGCAGGAACTCTCGGAAGCCTGGCTGCCACCAAT ACGTCATTCACAACAATAAGTGCATCCCCGAGTGCCCGTCTGGCTATACCATGAATTCCAGCAACTTGAT GTGCACCCCATGTCTGGGACCCTGCCCTAAGGTCTGCCAAATCCTCGAAGGTGAGAAGACCATTGATTCT GTGACATCTGCCCAGGAGCTCCGAGGCTGCACTGTGATCAACGGTAGCCTGATCATCAACATCCGAGGGG GCAACAACCTGGCAGCTGAGCTGGAGGCTAACCTTGGCCTCATTGAAGAAATTTCGGGATTTCTAAAGAT CCGCCGCTCCTATGCTCTGGTATCACTTTCTTTCTTCAGGAAGCTACATCTGATTCGAGGAGAGACCTTG GAAATTGGGAACTATTCTTTTTATGCCTTGGACAACCAGAACCTGAGGCAACTCTGGGACTGGAGCAAAC ACAACCTCACCATCACTCAGGGCAAGCTCTTCTTCCATTACAACCCGAAACTCTGCTTGTCTGAAATTCA CAAGATGGAAGAAGTCTCCGGAACTAAGGGCCGTCAGGAGAGGAACGACATTGCCCTGAAGACCAATGGG GACCAGGCATCGTGTGAAAATGAATTGCTTAAATTTTCTTTCATTCGGACATCTTTTGACAAGATCCTGT TGAGGTGGGAACCCTACTGGCCCCCCGACTTCCGAGATCTCCTGGGATTCATGTTGTTCTACAAAGAGGC CCCTTATCAGAATGTGACAGAGTTTGATGGGCAGGATGCTTGTGGCTCCAACAGCTGGACTGTGGTGGAT ATTGACCCGCCCCAGAGGTCCAACGACCCCAAGTCTCAGACCCCAAGCCACCCTGGGTGGCTGATGCGGG GCCTCAAACCCTGGACCCAATACGCCATCTTTGTGAAGACCTTGGTTACCTTCTCTGATGAACGGCGGAC CTATGGAGCCAAAAGTGATATCATCTATGTGCAAACAGATGCCACTAATCCTTCTGTCCCCCTGGATCCC ATATCAGTTTCTAATTCCTCATCTCAGATTATCTTAAAGTGGAAGCCCCCCTCTGACCCCAATGGCAACA TCACACACTACCTGGTGTACTGGGAGAGGCAAGCAGAGGACAGCGAGCTGTTTGAGCTGGATTATTGTCT CAAAGGGCTGAAGCTCCCTTCACGGACCTGGTCCCCACCCTTTGAGTCTGATGATTCTCAGAAGCACAAT CAGAGTGAGTATGACGACTCGGCCAGTGAGTGCTGCTCATGCCCTAAGACTGACTCTCAGATCCTGAAGG AGCTGGAGGAGTCTTCATTCAGGAAGACCTTCGAGGATTACCTGCACAACGTGGTTTTTGTCCCCAGGCC ATCCCGAAAGCGAAGATCCCTTGAAGAGGTGGGGAATGTGACAGCCACCACACTCACACTTCCAGATTTC CCCAACGTCTCCTCTACCATTGTGCCCACAAGTCAGGAGGAGCACAGGCCATTTGAGAAAGTGGTGAACA AGGAGTCACTTGTCATCTCTGGCCTGAGACACTTCACTGGGTACCGCATTGAGCTGCAGGCATGCAATCA AGATTCCCCAGATGAGAGGTGCAGTGTGGCTGCCTACGTCAGTGCCCGGACCATGCCTGAAGCTAAGGCA GATGACATCGTTGGCCCTGTGACTCATGAAATCTTTGAGAACAATGTTGTACACTTAATGTGGCAAGAGC CAAAGGAACCTAATGGTCTGATTGTGCTATATGAAGTGAGCTATCGCCGATATGGTGATGAGGAGCTGCA CCTCTGTGTCTCCCGGAAGCATTTTGCCCTGGAGCGGGGCTGCAGGCTGCGAGGGCTCTCCCCAGGAAAC TACAGTGTTCGAGTCCGGGCTACCTCTCTGGCAGGAAATGGCTCCTGGACAGAACCCACCTATTTTTATG TGACTGATTATTTAGATGTCCCATCAAATATTGCCAAAATTATCATTGGACCCCTCATCTTTGTCTTCCT CTTCAGTGTTGTGATTGGAAGTATTTATCTATTTCTGAGAAAGAGGCAGCCGGATGGGCCAATGGGACCA CTGTATGCATCTTCAAACCCTGAGTACCTCAGTGCCAGTGATGTGTTTCCATCTTCTGTGTACGTGCCGG ACGAGTGGGAGGTGCCTCGAGAGAAGATCACCCTTCTTCGAGAGCTGGGGCAGGGATCCTTTGGTATGGT GTATGAAGGCAATGCCAAGGATATCATCAAGGGTGAGGCAGAGACCCGTGTTGCGGTTAAGACTGTCAAT GAGTCAGCCAGTCTTCGAGAACGGATCGAGTTCCTCAATGAGGCATCAGTCATGAAGGGATTCACCTGCC ATCATGTGGTCCGCCTTCTTGGGGTGGTATCCAAAGGACAGCCAACGCTGGTAGTGATGGAATTGATGGC TCATGGAGACCTGAAAAGTCACCTCCGTTCTCTGAGGCCAGATGCTGAGAATAACCCAGGCCGCCCTCCC CCTACCTTGCAAGAAATGATTCAGATGACAGCAGAAATTGCTGATGGCATGGCATACTTGAACGCCAAGA AGTTTGTGCACCGGGACCTGGCAGCTCGAAACTGCATGGTTGCCCATGATTTTACTGTCAAAATTGGAGA CTTTGGAATGACAAGGGACATCTACGAGACAGATTACTATCGGAAAGGGGGCAAGGGACTGCTTCCTGTG AGGTGGATGTCACCTGAGTCCCTGAAGGATGGAGTCTTTACTGCTTCTTCTGATATGTGGTCCTTTGGGG TGGTCCTTTGGGAAATCACTAGCCTGGCTGAGCAACCTTATCAAGGCCTGTCTAATGAACAGGTGTTGAA GTTTGTCATGGATGGAGGCTATCTGGATCCCCCTGATAACTGTCCAGAGAGACTCACTGACCTGATGCGC ATGTGCTGGCAGTTCAACCCCAAGATGAGGCCAACCTTCCTGGAAATCGTCAACCTGCTCAAGGATGACC TCCACCCCAGCTTTCCAGAAGTTTCCTTCTTCTACAGCGAGGAGAACAAGGCTCCTGAGAGTGAGGAGCT GGAGATGGAGTTTGAAGACATGGAGAATGTCCCGTTGGATCGTTCCTCTCACTGTCAGAGAGAAGAGGCT GGGGGCCGGGAGGGAGGGTCCTCACTGAGCATCAAACGGACCTATGATGAACACATCCCCTATACCCACA TGAATGGGGGCAAGAAGAACGGACGTGTCCTTACCCTGCCAAGGTCAAACCCTTCCTAA ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT ACAAGGATGACGACGATAAGGTTTAA |
| Chromatograms |
CHROMATOGRAMS
 Sequencher program is needed, download here. |
| Restriction Sites | SgfI-MluI |
| ACCN | NM_010568 |
| Insert Size | 4119 bp |
| OTI Disclaimer | Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Reference Data | |
| RefSeq | NM_010568.2, NP_034698.2 |
| RefSeq Size | 9357 bp |
| RefSeq ORF | 4119 bp |
| Locus ID | 16337 |
| UniProt ID | P15208 |
| Gene Summary | This gene encodes a member of the receptor tyrosine kinase family of transmembrane signaling proteins that play important roles in cell differentiation, growth and metabolism. The encoded preproprotein undergoes proteolytic processing to generate alpha and beta chains that form a disulfide-linked heterodimer which, in turn homodimerizes to form a mature, functional receptor. Mice lacking the encoded protein develop severe hyperglycemia and hyperketonemia, and die within a couple of days after birth as a result of diabetic ketoacidosis. [provided by RefSeq, Aug 2016] Transcript Variant: This variant (1) represents the shorter transcript and encodes the shorter protein (isoform A). Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments and orthologous data. |
Citations (4)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
Unique ligand and kinase-independent roles of the insulin receptor in regulation of cell cycle, senescence and apoptosis.
,null,
Nature communications
,PubMed ID 36599833
[Insr]
|
|
FoxK1 and FoxK2 in insulin regulation of cellular and mitochondrial metabolism
,Sakaguchi, M;Cai, W;Wang, CH;Cederquist, CT;Damasio, M;Homan, EP;Batista, T;Ramirez, AK;Gupta, MK;Steger, M;Wewer Albrechtsen, NJ;Singh, SK;Araki, E;Mann, M;Enerbäck, S;Kahn, CR;,
Nat Commun
,PubMed ID 30952843
[INSR]
|
|
Domain-dependent effects of insulin and IGF-1 receptors on signalling and gene expression
,Cai, W;Sakaguchi, M;Kleinridders, A;Gonzalez-Del Pino, G;Dreyfuss, JM;O'Neill, BT;Ramirez, AK;Pan, H;Winnay, JN;Boucher, J;Eck, MJ;Kahn, CR;,
Nat Commun
,PubMed ID 28345670
[INSR]
|
|
Insulin and IGF-1 receptors regulate FoxO-mediated signaling in muscle proteostasis
,O'Neill, BT;Lee, KY;Klaus, K;Softic, S;Krumpoch, MT;Fentz, J;Stanford, KI;Robinson, MM;Cai, W;Kleinridders, A;Pereira, RO;Hirshman, MF;Abel, ED;Accili, D;Goodyear, LJ;Nair, KS;Kahn, CR;,
J. Clin. Invest.
,PubMed ID 27525440
[Insr]
|
Documents
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| SDS |
Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| MG227067 | Insr (tGFP-tagged) - Mouse insulin receptor (Insr), (10ug) |
CNY 15,680.00 |
|
| MR227067 | Insr (Myc-DDK-tagged) - Mouse insulin receptor (Insr) |
CNY 14,080.00 |
|
| MR227067L3 | Lenti ORF clone of Insr (Myc-DDK-tagged) - Mouse insulin receptor (Insr) |
CNY 15,580.00 |
|
| MR227067L4 | Lenti ORF clone of Insr (mGFP-tagged) - Mouse insulin receptor (Insr) |
CNY 15,580.00 |
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