Mapk8ip3 (NM_001163451) Mouse Untagged Clone
CAT＃: MC224198
Mapk8ip3 (untagged) - Mouse mitogen-activated protein kinase 8 interacting protein 3 (Mapk8ip3), transcript variant 6, (10ug)
CNY 16820.00
Product images
Specifications
| Product Data | |
| Type | Mouse Untagged Clone |
| Tag | Tag Free |
| Synonyms | BB120594; D17Wsu15e; JIP-3; Jip3; JSAP1; JSAP1a; JSAP1b; JSAP1c; JSAP1d; mKIAA1066; Syd2 |
| Vector | pCMV6-Entry |
| E. coli Selection | Kanamycin (25 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data |
>MC224198 representing NM_001163451
Red=Cloning site Blue=ORF Orange=Stop codon TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC GCCGCGATCGCC ATGATGGAGATCCAGATGGACGAGGGAGGAGGAGTGGTGGTGTACCAAGACGACTACTGCTCGGGCTCGG TCATGTCGGAGCGTGTGTCGGGCCTGGCGGGCTCCATCTACCGCGAGTTCGAGCGCCTCATTCACTGCTA TGACGAGGAGGTGGTCAAGGAGCTCATGCCGCTGGTGGTGAACGTGCTGGAGAACCTTGACTCGGTGCTG AGCGAGAACCAGGAGCACGAGGTGGAGCTGGAGCTCCTACGCGAGGACAACGAGCAGCTGCTCACGCAAT ACGAGCGCGAGAAGGCGCTGCGCAAACAGGCCGAGGAGAAATTCATCGAATTTGAAGATGCCTTGGAACA AGAGAAGAAAGAACTCCAGATCCAGGTAGAACATTATGAGTTTCAGACACGCCAGCTGGAGCTAAAGGCC AAAAACTATGCAGATCAGATTTCCCGACTGGAGGAACGAGAATCGGAGATGAAGAAGGAATACAATGCCC TGCACCAGCGGCACACAGAGATGATCCAGACCTATGTGGAACACATTGAAAGATCCAAGATGCAGCAAGT TGGGGGTAGCGGCCAAACAGAAAGCAGCCTGCCCGGGCGGAGGAAGGAGCGTCCCACCTCTCTGAATGTC TTCCCCCTGGCTGATGGCATGTGTCCAAATGATGAGATGTCTGAGTCAGGCCAGTCCTCAGCAGCTGCAA CACCCAGTACCACAGGTACCAAGTCCAACACACCCACGTCCTCCGTGCCCTCAGCAGCAGTCACGCCACT CAACGAGAGCCTACAGCCCCTGGGGGACTATGTCAGTGTCACAAAGAACAACAAGCAGGCCCGAGAGAAG CGCAATAGCCGTAACATGGAGGTCCAGGTCACCCAAGAGATGCGGAACGTCAGTATCGGCATGGGCAGCA GTGACGAGTGGTCCGATGTTCAGGACATTATCGACTCCACCCCAGAGCTGGATGTGTGTCCTGAAACCCG TCTGGAGCGCACAGGAAGCAGCCCAACCCAGGGAATTGTAAACAAAGCTTTTGGAATCAACACTGACTCC TTGTATCACGAACTCTCCACGGCGGGATCTGAGGTCATCGGGGATGTGGACGAGGGAGCTGATCTCCTAG GGGAGTTTTCAGTGCGCGATGATTTTTTTGGAATGGGCAAAGAAGTGGGGAACCTGCTGCTGGAGAACTC ACAGCTTCTAGAGACAAAAAATGCTTTAAATGTAGTGAAGAATGACCTCATTGCTAAGGTTGACCAACTG TCAGGAGAACAGGAGGTCCTGAAGGGTGAGCTGGAAGCAGCCAAGCAAGCCAAAGTCAAGCTGGAGAACC GAATCAAAGAGCTTGAAGAAGAACTGAAGAGAGTCAAGTCAGAGGCAGTAACTGCCCGCCGTGAGCCCAG AGAAGAGGTGGAGGATGTAAGCAGCTATCTCTGTACAGAATTGGACAAAATCCCCATGGCCCAGCGCCGA CGCTTCACACGGGTGGAGATGGCCCGAGTGCTCATGGAACGCAACCAGTACAAGGAACGCCTCATGGAGC TGCAGGAGGCTGTGAGGTGGACTGAAATGATCAGAGCATCAAGGGAACACCCATCTGTCCAGGAGAAGAA GAAGTCCACCATCTGGCAGTTCTTTAGTCGCCTCTTCAGCTCCTCATCTAGCCCCCCTCCGGCCAAACGA TCCTACCCATCTGTGAACATTCACTACAAGTCACCCACTGCAGCTGGCTTTAGCCAGCGTCGCAGCCATG CTTTGTGCCAGATCTCAGCCGGCAGCAGGCCCCTGGAGTTCTTCCCTGATGATGACTGCACCTCTTCTGC CCGGCGGGAGCAGAAGCGGGAGCAGTACCGCCAGGTTCGTGAACACGTGCGCAATGATGACGGGAGGCTG CAGGCCTGTGGGTGGAGCCTGCCTGCCAAGTACAAGCAGCTGAGCCCCAATGGAGGCCAGGAAGACACCC GGATGAAAAATGTGCCTGTCCCTGTGTACTGCCGCCCTCTGGTGGAGAAGGACCCTTCGACAAAGCTGTG GTGTGCTGCTGGTGTCAACCTGAGTGGGTGGAAGCCACATGAAGAGGACTCTAGCAATGGACCCAAGCCT GTACCAGGTCGAGACCCTCTGACCTGTGACCGGGAAGGAGAAGGCGAACCCAAGAGCACACACCCATCAC CTGAGAAGAAGAAGGCAAAGGAAACCCCTGAGGCAGATGCTACCTCCAGTCGGGTATGGATCCTCACCAG CACCCTGACAACCAGCAAGGTGGTGATCATTGATGCCAACCAGCCAGGCACAATTGTGGATCAGTTCACA GTCTGCAATGCCCACGTCCTGTGTATCTCCAGCATTCCTGCGGCCAGTGACAGTGACTATCCCCCTGGGG AGATGTTCCTAGACAGTGATGTGAACCCTGAAGATTCAGGTGCTGATGGTGTGCTGGCTGGCATCACCCT GGTGGGGTGTGCTACCCGCTGCAATGTTCCACGTAGCAACTGTTCCTCACGAGGAGACACCCCAGTACTG GACAAGGGGCAGGGGGATGTGGCGACCACTGCCAATGGGAAGGTCAACCCGTCCCAATCCACAGAAGAAG CCACAGAAGCCACGGAGGTGCCAGACCCTGGTCCCAGCGAGTCAGAAGCAACGACAGTCCGGCCCGGGCC TCTCACAGAGCATGTCTTTACTGACCCAGCACCCACCCCATCCTCCAGCACCCAGCCTGCCAGTGAGAAT GGGTCAGAGTCCAATGGCACCATTGTACAGCCTCAGGTGGAGCCCAGTGGGGAACTCTCAACAACAACCA GTAGCGCTGCACCCACTATGTGGCTAGGAGCCCAGAATGGCTGGCTCTATGTGCATTCAGCGGTAGCCAA CTGGAAGAAGTGTCTGCACTCCATCAAGCTAAAAGACTCTGTGCTGAGCCTGGTGCATGTCAAAGGCCGA GTGCTGGTAGCTCTTGCAGATGGGACCCTGGCTATCTTCCATCGTGGAGAGGATGGCCAGTGGGACCTGA GCAACTACCACCTAATGGACCTGGGCCACCCACACCACTCCATCCGCTGCATGGCTGTTGTGAATGACCG AGTTTGGTGTGGCTACAAGAACAAGGTGCATGTTATCCAGCCCAAGACAATGCAGATTGAGAAATCATTT GATGCCCACCCAAGGCGGGAAAGCCAGGTACGTCAGCTGGCCTGGATCGGTGATGGAGTGTGGGTCTCTA TTCGCTTGGATTCTACCCTTCGGCTCTACCATGCTCACACCCACCAGCACCTGCAGGATGTGGACATTGA GCCCTATGTTAGCAAGATGCTAGGAACCGGCAAGCTGGGCTTCTCCTTCGTGCGCATCACAGCCTTACTC ATTGCAGGCAACCGTCTGTGGGTGGGCACTGGCAATGGGGTTGTCATCTCCATCCCCTTGACTGAGACTG TGGTCCTGCATCGAGGCCAGCTCCTAGGGCTCCGAGCCAACAAGACATCCCCAACATCTGGGGAGGGGAC CCGCCCAGGGGGCATCATCCATGTGTATGGGGACGACAGCAGTGACAAGGCCGCCAGTAGTTTCATCCCC TACTGCTCCATGGCACAGGCTCAGCTTTGCTTCCATGGGCACCGTGATGCTGTCAAATTCTTTGTCTCTG TGCCAGGAAATGTGCTGGCCACTCTCAATGGCAGTGTGCTAGACAGCCCATCAGAGGGCCCTGGGCCTGC TGCACCCGCTGCAGATGCTGAGGGCCAGAAGTTGAAGAATGCACTGGTGCTGAGTGGTGGTGAAGGTTAC ATTGACTTCCGTATCGGAGACGGAGAGGATGATGAAACTGAGGAATGTGCCGGGGACGTGAACCAGACAA AGCCCTCGTTGTCCAAGGCTGAGCGCAGCCACATCATCGTGTGGCAGGTGTCCTACACCCCTGAGTGA ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT ACAAGGATGACGACGATAAGGTTTAA |
| Restriction Sites | SgfI-MluI |
| ACCN | NM_001163451 |
| Insert Size | 3918 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_001163451.1, NP_001156923.1 |
| RefSeq Size | 5483 bp |
| RefSeq ORF | 3918 bp |
| Locus ID | 30957 |
| UniProt ID | Q9ESN9 |
| Gene Summary | The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins (PubMed:10523642, PubMed:10629060). Promotes neuronal axon elongation in a kinesin- and JNK-dependent manner (PubMed:23576431, PubMed:25944905, PubMed:28259553). Activates cofilin at axon tips via local activation of JNK, thereby regulating filopodial dynamics and enhancing axon elongation (PubMed:23576431, PubMed:25944905, PubMed:28259553). Its binding to kinesin heavy chains (KHC), promotes kinesin-1 motility along microtubules and is essential for axon elongation and regeneration (PubMed:23576431, PubMed:25944905, PubMed:28259553). Regulates cortical neuronal migration by mediating NTRK2/TRKB anterograde axonal transport during brain development (PubMed:23576431, PubMed:25944905, PubMed:28259553). Acts as an adapter that bridges the interaction between NTRK2/TRKB and KLC1 and drives NTRK2/TRKB axonal but not dendritic anterograde transport, which is essential for subsequent BDNF-triggered signaling and filopodia formation (PubMed:23576431, PubMed:25944905, PubMed:28259553).[UniProtKB/Swiss-Prot Function] Transcript Variant: This variant (6) uses two alternate in-frame splice sites in the 5' coding region compared to variant 1. This results in a shorter protein (isoform f) compared to isoform a. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. |
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| MG223086 | Mapk8ip3 (tGFP-tagged) - Mouse mitogen-activated protein kinase 8 interacting protein 3 (Mapk8ip3) transcript variant 6, (10ug) |
CNY 14350.00 |
|
| MR223086 | Mapk8ip3 (Myc-DDK-tagged) - Mouse mitogen-activated protein kinase 8 interacting protein 3 (Mapk8ip3), transcript variant 6 |
CNY 13020.00 |
|
| MR223086L3 | Lenti ORF clone of Mapk8ip3 (Myc-DDK-tagged) - Mouse mitogen-activated protein kinase 8 interacting protein 3 (Mapk8ip3), transcript variant 6 |
CNY 14920.00 |
|
| MR223086L4 | Lenti ORF clone of Mapk8ip3 (mGFP-tagged) - Mouse mitogen-activated protein kinase 8 interacting protein 3 (Mapk8ip3), transcript variant 6 |
CNY 14920.00 |
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