Dyrk1a (NM_001113389) Mouse Untagged Clone
CAT＃: MC221423
Dyrk1a (untagged) - Mouse dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1a (Dyrk1a), transcript variant 2, (10ug)
CNY 9880.00
Product images
Specifications
| Product Data | |
| Type | Mouse Untagged Clone |
| Tag | Tag Free |
| Synonyms | 2310043O08Rik; D16Ertd272e; D16Ertd493e; Dyrk; ENSMUSG00000074897; Gm10783; mmb; Mnbh; Mp86 |
| Vector | pCMV6-Entry |
| E. coli Selection | Kanamycin (25 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data |
>MC221423 representing NM_001113389
Red=Cloning site Blue=ORF Orange=Stop codon TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC GCCGCGATCGCC ATGCATACAGGAGGAGAGACTTCAGCATGCAAACCTTCATCTGTCCGGCTTGCACCGTCGTTCTCATTCC ATGCTGCTGGCCTTCAGATGGCTGCACAGATGCCCCACTCACACCAGTACAGTGACCGTCGCCAGCCGAG CATAAGTGACCAGCAGGTGTCTGCCTTACCATATTCTGACCAGATTCAGCAACCTCTAACTAACCAGGTG ATGCCTGACATTGTCATGTTACAGAGGCGGATGCCCCAAACCTTCCGTGATCCAGCAACTGCTCCTCTGA GAAAACTCTCTGTGGACTTGATCAAAACATACAAGCATATTAATGAGGTTTACTATGCAAAAAAGAAGCG AAGACACCAACAGGGCCAGGGGGACGATTCCAGTCATAAGAAGGAGCGGAAGGTTTACAATGATGGTTAC GATGATGATAACTATGATTATATTGTAAAAAACGGGGAAAAGTGGATGGATCGGTATGAAATCGACTCCT TAATAGGCAAAGGTTCATTTGGACAGGTTGTGAAAGCTTATGACAGAGTGGAGCAAGAATGGGTCGCCAT TAAAATCATCAAGAACAAGAAAGCGTTTCTGAATCAAGCCCAGATAGAAGTGCGGCTGCTTGAGCTCATG AACAAACACGACACTGAAATGAAGTACTACATAGTGCATTTGAAACGCCACTTTATGTTTCGAAACCATC TCTGTTTAGTGTTTGAAATGCTGTCCTATAATCTCTATGATTTGTTGAGAAACACCAACTTCCGAGGGGT CTCTTTGAACCTAACACGAAAGTTTGCGCAACAGATGTGCACAGCATTGCTTTTTCTTGCGACTCCAGAA CTTAGTATCATTCACTGTGACTTAAAGCCTGAGAACATCCTTCTGTGTAACCCCAAACGGAGTGCAATCA AGATTGTTGATTTTGGCAGCTCTTGTCAGTTGGGGCAGAGGATATACCAGTATATTCAGAGTCGCTTTTA TCGGTCTCCAGAGGTGCTACTGGGAATGCCTTATGACCTTGCTATCGACATGTGGTCCCTTGGATGTATC TTGGTTGAAATGCACACTGGAGAGCCTCTGTTCAGTGGTGCCAATGAGGTCGATCAGATGAATAAAATAG TGGAAGTCTTGGGCATCCCACCTGCTCATATTCTTGACCAAGCACCGAAAGCAAGAAAGTTCTTTGAGAA GTTGCCCGATGGCACTTGGAGCTTAAAGAAGACCAAAGATGGAAAACGGGAGTACAAACCACCAGGAACC CGTAAACTTCATAATATTCTTGGAGTAGAAACAGGAGGACCTGGCGGGCGGCGTGCTGGGGAATCGGGTC ATACTGTAGCTGACTACTTGAAGTTCAAAGACCTCATTTTAAGGATGCTTGATTATGACCCCAAAACTCG GATTCAACCTTATTATGCCCTGCAGCACAGTTTTTTCAAGAAAACAGCTGATGAAGGTACCAACACAAGT AACAGTGTGTCTACCAGCCCTGCGATGGAGCAGTCTCAGTCTTCAGGCACCACCTCCAGCACCTCCTCCA GCTCAGGTGGATCCTCGGGAACGAGTAACAGTGGGAGAGCCAGGTCGGATCCGACGCACCAGCATCGACA CAGCGGTGGACACTTCGCTGCTGCTGTCCAGGCCATGGACTGTGAGACACACAGTCCCCAGGTGCGCCAG CAGTTTCCGGCTCCTCTGGGATGGTCAGGCACTGAAGCTCCTACACAAGTCACTGTTGAAACTCATCCTG TTCAAGAGACAACCTTTCATGTAGCCCCCCAGCAGAACGCATTGCATCATCACCATGGAAACAGTTCCCA TCACCACCACCACCACCATCACCACCACCACCACCATGGACAGCAAGCCTTGGGTAACCGGACCAGGCCA AGGGTCTACAATTCTCCAACAAATAGCTCCTCTACCCAGGATTCTATGGAGGTTGGCCACAGTCACCACT CCATGACATCCCTGTCTTCCTCAACAACTTCTTCCTCGACATCTTCCTCCTCTACTGGTAATCAAGGCAA TCAGGCCTATCAGAACCGCCCAGTGGCTGCTAACACCTTGGACTTTGGACAGAATGGAGCTATGGACGTT AATTTGACCGTCTACTCCAATCCCCGCCAAGAGACTGGCATAGCTGGACATCCAACATACCAATTTTCTG CTAATACAGGTCCTGCACATTACATGACTGAAGGACATCTGGCGATGAGACAAGGGGCTGATAGAGAAGA GTCTCCCATGACAGGAGTTTGTGTGCAACAGAGTCCTGTAGCTAGCTCGTGA ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT ACAAGGATGACGACGATAAGGTTTAA |
| Restriction Sites | SgfI-MluI |
| ACCN | NM_001113389 |
| Insert Size | 2292 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_001113389.1, NP_001106860.1 |
| RefSeq Size | 5776 bp |
| RefSeq ORF | 2292 bp |
| Locus ID | 13548 |
| UniProt ID | Q61214 |
| Gene Summary | Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities. May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Modulates alternative splicing by phosphorylating the splice factor SRSF6 (By similarity). Exhibits a substrate preference for proline at position P+1 and arginine at position P-3. Has pro-survival function and negatively regulates the apoptotic process. Promotes cell survival upon genotoxic stress through phosphorylation of SIRT1. This in turn inhibits TP53 activity and apoptosis (PubMed:20167603).[UniProtKB/Swiss-Prot Function] Transcript Variant: This variant (2) uses an alternate 5' non-coding exon, therefore, has a different 5' UTR compared to transcript variant 1. Transcript variants 1 and 2 encode the same protein. |
Documents
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| MG222954 | Dyrk1a (tGFP-tagged) - Mouse dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1a (Dyrk1a) transcript variant 2, (10ug) |
CNY 6370.00 |
|
| MR222954 | Dyrk1a (Myc-DDK-tagged) - Mouse dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1a (Dyrk1a), transcript variant 2 |
CNY 5592.00 |
|
| MR222954L3 | Lenti ORF clone of Dyrk1a (Myc-DDK-tagged) - Mouse dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1a (Dyrk1a), transcript variant 2 |
CNY 7700.00 |
|
| MR222954L4 | Lenti ORF clone of Dyrk1a (mGFP-tagged) - Mouse dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1a (Dyrk1a), transcript variant 2 |
CNY 7700.00 |
