Uimc1 (NM_011307) Mouse Untagged Clone
CAT＃: MC221087
Uimc1 (untagged) - Mouse ubiquitin interaction motif containing 1 (Uimc1), (10ug)
CNY 9310.00
Product images
Specifications
| Product Data | |
| Type | Mouse Untagged Clone |
| Tag | Tag Free |
| Synonyms | 9430016E08Rik; D330018D10Rik; D630032M02Rik; RIP110; Rxrip110 |
| Vector | pCMV6-Entry |
| E. coli Selection | Kanamycin (25 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data |
>MC221087 representing NM_011307
Red=Cloning site Blue=ORF Orange=Stop codon TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC GCCGCGATCGCC ATGCCACGAAGGAAGAAAAAAATTAAAGAGGCCTCTGAAAGCCAGAACTTGGAGAAGAAGGATCTGGAAA CAAGCAGTTGTGTCAGTATAAAGAAGAAGCGTAGACTTGAGGACTTACTCATAGTGATATCCGATAGCGA TGGAGAGGAAACAAAAGAGGAGAATGGATTGCAGAAAACGAAGACAAAACAGTCGAACAGATCAAAGTGT TTGGCTAAAAGAAAAGTTGCACACATGTCAGAAGAAGAACAATTTGCTTTGGCTCTCAAGATGAGTGAGC AGGAAGCTAGGGAGGTGAATAACCAGGAGGAGAAAGAAGAGGAGCTCTTGCGGAAAGCCATTGCTGAAAG CCTGAATAGTTGCTGGTCTTCTGCTGCTTCTGCTACCAGATCTCGACCTCTGGCTGCTGAACTATCTTCA CATTCCCATCAAGAGAACACCAAAGACTCTGGGACCACTGAAGGCGTATGGCAGCTGGTACCTCCATCAC TGTGTAAAGGCTCACATGTCAGTCAGGGAAACGAGGCTGAGCAAAGAAAGGAGCCCTGGGACCACAATGA AAACACTGAAGAGGAGCCGGTCTCTGGCAGCTCAGGAAGCTGGGACCAGTCAAGCCAGCCAGTGTTTGAG AATGAGAACGTTAAATGTTTTGACAGATGTACTGGCCACTTGGCTGAGCACACACAGTGTGGGAAGCCAC AGGAAAGTACTGGGAGTGGTTATGCTTTTTCCAAAGCTGTCCAGGGTAGGGGGGACACGTCTAGGCAATG CCTTCCTATCCCAGCAGACACAAAAGGTCTCCAGGACACTGGGGGCACTGTGCACTACTACTGGGGTATT CCATTCTGCCCTGCTGGAGTAGATCCCAATCAATACACCAATGTCATTCTCTGCCAGTTAGAGGTTTATC AGAAGAGCCTGAAAATGGCTCAGAGACAGCTTGTTAAAAAAAGAGGGTTTGGGGAACCAGTGTTACCTAG ACCTCCTTTTCTGATCCAGAATGAATGTGGCCAAGAAGATCAGACTAGTGACAAAAATGAAGGCATCTCA GAAGATATGGGAGATGAAGCCAAAGAGGAAAGGCAGGAATCTAGGGCATCTGTCTGGCACTCAGAAACCA AGGATTTTCAAAAAAGTCCAATTAAAAGCTTGAAACAGAAACTTTTGTTGGAGGAAGAACCAACAACCAG TCGTGGTCAGTCTTCCCAAGGTCTGTTTGTTGAAGAAACCTCTGAAGAAGGTCTGAAGAGTTCTGAAGGA GACAACTCTGTGCCCACCACGCAAAGCATTGCAGCTTTGACCAGTAAGAGAAGTTTAGTTCTTATGCCGG AAAGTTCTGCAGAAGAAACCACTGTTTGCCCTGAGACACAGTTAAGTTTCCTTGAACCCCTTGACCTCAA TAGAGAAGACTCTCCAGATAGCAGAGAGCTCCCCATTGAAGTAAGGATGGCAGTGGGCGATAAGCAGGTT GCTAATAGGGAAGATTGTATGAAGGAAAACCCTCCTCCTGCAGTCTCATCTAGTACCCGGGTATCCTGCC CACTGTGTAACCAAGACTTTCCTCCCACAAAGATTGAACAGCATGCCATGTACTGCAATGGTCTGATGGA GCAGGAAACAGTGTTGACTCGGAGACGAAGAGAGGCCAAGAACAAGAGTGACGGTCGGACAGCTGCACAG CCGGCTCTGGATGCCAACAGGAAGGAGAAGTGTTATCTATGTAAGTCCCTGGTTCCACTTGGGGAGTATC AGTGCCATGTGGAGGCCTGTCTCCAGCTTGCAAAGGTTGACAGAGAAGATGGGATTGAAGGGACAAGGAG ACCAAGGGTGTGTGCACCTGTGGAGGGGAAACAACAGCAGCGGCTGAAGAAGTCAAAGGACAAAGGCCAT AGTCAAGGCCGACTCCTCAGTCTCTTGGAGCAGTCTGAGCATAGGACCACAGGTGTAGAGAAAAAACCCA AGTATTCGGAAGTAAGAACCTTCAGGATGCCCTCACCAGAGGTGGAAGAGGCTAGCTGCAGCAGAGAGAT GCAGAGTACCCTCTCACAGCTCAACTTAAATGAGTCTCCCATCAAGTCTTTTGTTCCTGTTTCAGAAGCT ACAAATTGCTTAGTGGACTTTAAAGAACAGTTTGCTTTCCGGTCACGAACTAAATCAGGCAGAGGAAGGA GGAGAAAATCTTGA ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT ACAAGGATGACGACGATAAGGTTTAA |
| Restriction Sites | SgfI-MluI |
| ACCN | NM_011307 |
| Insert Size | 2184 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_011307.2, NP_035437.1 |
| RefSeq Size | 2931 bp |
| RefSeq ORF | 2184 bp |
| Locus ID | 20184 |
| UniProt ID | Q5U5Q9 |
| Gene Summary | Ubiquitin-binding protein. Specifically recognizes and binds 'Lys-63'-linked ubiquitin (PubMed:19536136). Plays a central role in the BRCA1-A complex by specifically binding 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. Also weakly binds monoubiquitin but with much less affinity than 'Lys-63'-linked ubiquitin. May interact with monoubiquitinated histones H2A and H2B; the relevance of such results is however unclear in vivo. Does not bind Lys-48'-linked ubiquitin. May indirectly act as a transcriptional repressor by inhibiting the interaction of NR6A1 with the corepressor NCOR1 (By similarity).[UniProtKB/Swiss-Prot Function] Transcript Variant: This variant (1) encodes the longest isoform (1). |
Documents
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| MG221571 | Uimc1 (tGFP-tagged) - Mouse ubiquitin interaction motif containing 1 (Uimc1), (10ug) |
CNY 6370.00 |
|
| MR221571 | Uimc1 (Myc-DDK-tagged) - Mouse ubiquitin interaction motif containing 1 (Uimc1) |
CNY 5320.00 |
|
| MR221571L3 | Lenti ORF clone of Uimc1 (Myc-DDK-tagged) - Mouse ubiquitin interaction motif containing 1 (Uimc1) |
CNY 7700.00 |
|
| MR221571L4 | Lenti ORF clone of Uimc1 (mGFP-tagged) - Mouse ubiquitin interaction motif containing 1 (Uimc1) |
CNY 7700.00 |
