Loxl3 (NM_013586) Mouse Untagged Clone
CAT＃: MC205696
Loxl3 (untagged) - Mouse lysyl oxidase-like 3 (Loxl3), (10ug)
CNY 5528.00
Product images
Specifications
| Product Data | |
| Type | Mouse Untagged Clone |
| Tag | Tag Free |
| Synonyms | Lor2; Loxl2 |
| Vector | PCMV6-Kan/Neo |
| E. coli Selection | Kanamycin (25 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data |
>BC011298
GAAAGTAATCTCCAGGACCAGGACTCTGCTTCCAGCCTCTGGAGTTGTGCCTAGTCGAAGTGCCCCCCTC CTTGGGCCCCACCCGCCATGAGAGCTGTCAGTGTGTGGTATTGCTGCCCATGGGGACTACTGCTGCTACA CTGTCTGTGCAGCTTCAGTGTGGGGTCTCCGTCTCCTTCTATCAGCCCAGAGAAGAAGGTAGGAAGCCAG GGGCTGAGGTTCCGGCTGGCTGGCTTTCCTAGAAAGCCCTATGAAGGTCGAGTGGAGATACAGCGAGCTG GTGAATGGGGCACCATCTGTGATGATGACTTCACGCTGCAGGCTGCCCATGTCCTCTGCCGGGAGCTGGG CTTCACAGAAGCCACAGGGTGGACTCATAGTGCCAAATATGGCCCTGGAACAGGCCGAATCTGGTTGGAC AATCTGAGCTGCAGGGGGACTGAAGGAAGTGTGACAGAATGCGCCTCTCGGGGCTGGGGAAACAGTGACT GTACCCATGATGAGGATGCCGGGGTCATCTGCAAGGACCAGCGCCTTCCCGGTTTCTCAGACTCCAACGT CATTGAGGTGGAGCATCAGTTGCAAGTGGAGGAGGTGCGACTCCGACCTGCGGTGGAGTGGGGAAGGAGA CCCCTGCCTGTGACTGAGGGCCTGGTTGAAGTCAGGCTTCCTGAAGGCTGGTCGCAAGTGTGTGACAAAG GCTGGAGTGCCCACAACAGCCACGTAGTCTGCGGTATGCTGGGCTTCCCTGGAGAAAAGAGAGTCAACAT GGCCTTCTACAGGATGCTGGCCCAGAAGAAGCAACACTCCTTTGGTCTGCACAGTGTGGCATGTGTGGGC ACAGAAGCCCACCTCTCCCTTTGCTCTCTAGAGTTCTATCGTGCCAATGACACCACCAGGTGCTCTGGGG GAAACCCTGCAGTGGTGAGCTGTGTGCTGGGCCCTCTTTATGCCACCTTTACTGGTCAGAAGAAGCAGCA ACACTCTAAGCCTCAAGGGGAGGCTCGTGTGCGTCTAAAGGGTGGTGCCCACCAGGGAGAAGGCAGAGTG GAAGTCCTGAAGGCTGGCACATGGGGAACAGTCTGTGACCGAAAGTGGGACCTGCAGGCAGCCAGTGTGG TGTGTCGAGAACTGGGCTTTGGCACTGCCCGAGAGGCCCTGAGTGGTGCCCGCATGGGGCAGGGCATGGG TGCCATCCACTTGAGTGAAGTTCGGTGCTCTGGCCAGGAGCCCTCCCTTTGGAGATGCCCGTCCAAGAAC ATCACAGCTGAGGACTGTTCCCACAGCCAGGATGCGGGTGTCCGGTGCAACCTCCCCTACACTGGGGTGG AGACCAAGATCCGACTCAGTGGGGGCCGCAGCCGGTATGAAGGGCGAGTCGAGGTGCAAATAGGGATACC TGGGCATCTACGCTGGGGCCTCATCTGTGGGGATGACTGGGGAACCCTGGAGGCCATGGTGGCCTGTAGG CAACTTGGTCTTGGCTACGCCAACCACGGCCTGCAGGAGACCTGGTACTGGGACTCAGGGAATGTAACTG AGGTGGTGATGAGCGGAGTGCGTTGCACGGGGTCTGAGCTGTCCCTGAACCAGTGTGCCCATCACAGCAG CCACATCACCTGCAAGAAGACGGGAACCCGCTTCACTGCGGGGGTCATCTGTTCTGAAACTGCTTCAGAT CTGCTGCTGCACTCGGCACTGGTACAGGAAACTGCTTATATTGAAGACCGGCCCTTGCACATGTTGTACT GTGCTGCTGAAGAGAACTGCCTGGCTAGCTCTGCCCGCTCGGCCAACTGGCCTTATGGCCACCGGCGTCT GCTCCGATTCTCTTCCCAGATCCACAACCTAGGAAGAGCTGACTTTAGGCCCAAGGCTGGGCGCCATTCC TGGGTGTGGCATGAGTGTCATGGGCATTACCACAGTATGGACATCTTCACTCATTATGATATCCTGACCC CCAATGGCACCAAGGTGGCTGAGGGCCACAAAGCTAGTTTCTGTCTAGAAGACACTGAGTGTCAAGAGGA TGTCTCCAAGAGGTATGAGTGCGCCAACTTTGGAGAGCAGGGCATCACCGTGGGATGTTGGGATCTCTAC AGGCATGACATTGACTGTCAGTGGATCGACATCACAGATGTGAAGCCAGGAAACTACATTCTTCAGGTCG TTATCAACCCAAATTTTGAGGTAGCAGAAAGTGACTTCACCAACAATGCAATGAAGTGTAACTGCAAATA CGACGGGCATCGCATCTGGGTGCACAACTGCCACATCGGTGATGCCTTCAGCGAAGAAGCCAACAGGAGG TTTGAGCGCTACCCTGGCCAGACTAGTAACCAGATCGTCTAAAATGCTACCACCCTCTCTGTAAACCACC ACTGGCCCCCAATGGCAGGGGTCTGAGGCTGCCATTACCTCAGGAGCTTACCACAAGAACCCCTGATGTC AGCAGGCGCCCTACACTCAACCACCTGTGCACTACAGGCAACAAACTGTCAAACAGAAGTTGGTGCCTCC TTTACGGGGTCAGCTGTCATTACCTTTGGCCAACAAGCATGGAGAATCAGCCAACAGCCCCAGCAACAGA CAGAACACACCACAAAGAACTGCCCCACACAGGATGGCAGCAGCTCATTCTCTTGAATAGGGGAGGTCAA GAGGGTCAGCTCCCATCGCTCTCCGTTCTCCTAAGGACCGCGTTACCTCTAGCCATTTGGTGGGGGAGAA GATCCAACCCCCACTTTTGACTGTAACATGTTGCTAGGTATAATTTTATTTTATATAAAATGTGTTCTTC GGAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA |
| Restriction Sites | RsrII-NotI |
| ACCN | NM_013586 |
| Insert Size | 2265 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | BC011298, AAH11298 |
| RefSeq Size | 2837 bp |
| RefSeq ORF | 2265 bp |
| Locus ID | 16950 |
| UniProt ID | Q9Z175 |
| Gene Summary | Protein-lysine 6-oxidase that mediates the oxidation of peptidyl lysine residues to allysine in target proteins (PubMed:26954549). Catalyzes the post-translational oxidative deamination of peptidyl lysine residues in precursors of elastin and different types of collagens, a prerequisite in the formation of cross-links between collagens and elastin (PubMed:26307084). Required for somite boundary formation by catalyzing oxidation of fibronectin (FN1), enhancing integrin signaling in myofibers and their adhesion to the myotendinous junction (MTJ) (PubMed:26954549). Acts as a regulator of inflammatory response by inhibiting differentiation of naive CD4(+) T-cells into T-helper Th17 or regulatory T-cells (Treg): acts by interacting with STAT3 in the nucleus and catalyzing both deacetylation and oxidation of lysine residues on STAT3, leading to disrupt STAT3 dimerization and inhibit STAT3 transcription activity (PubMed:28065600). Oxidation of lysine residues to allysine on STAT3 preferentially takes place on lysine residues that are acetylated (By similarity). Also able to catalyze deacetylation of lysine residues on STAT3 (By similarity).[UniProtKB/Swiss-Prot Function] |
Documents
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| MR210480 | Loxl3 (Myc-DDK-tagged) - Mouse lysyl oxidase-like 3 (Loxl3) |
CNY 5528.00 |
|
| MR210480L3 | Lenti ORF clone of Loxl3 (Myc-DDK-tagged) - Mouse lysyl oxidase-like 3 (Loxl3) |
CNY 7700.00 |
|
| MR210480L4 | Lenti ORF clone of Loxl3 (mGFP-tagged) - Mouse lysyl oxidase-like 3 (Loxl3) |
CNY 7700.00 |
