Hmgb2 (NM_008252) Mouse Untagged Clone
CAT＃: MC202770
Hmgb2 (untagged) - Mouse high mobility group box 2 (Hmgb2), (10ug)
CNY 2400.00
Product images
Specifications
| Product Data | |
| Type | Mouse Untagged Clone |
| Tag | Tag Free |
| Synonyms | C80539; HMG-2; Hmg2 |
| Vector | PCMV6-Kan/Neo |
| E. coli Selection | Kanamycin (25 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data |
>BC083108 sequence for NM_008252
GCCGGAGCTTGGGGAAGGAAGTCTCTCTGCGGAGGTCTGAGGGAAGCAGCGCTCGCAGCAGGTAGACAGA CGCCGCGCCGTCGTCATGGGCAAGGGTGACCCCAACAAGCCGCGGGGCAAAATGTCCTCGTACGCCTTCT TCGTGCAGACCTGCCGCGAGGAGCACAAGAAGAAGCATCCCGACTCGTCGGTGAACTTCGCCGAGTTCTC CAAGAAATGCTCCGAGAGATGGAAGACCATGTCTGCAAAGGAAAAGTCCAAGTTTGAAGATTTGGCCAAG AGCGACAAAGCTCGTTATGACAGGGAGATGAAGAACTATGTTCCTCCCAAAGGGGATAAGAAAGGAAAGA AAAAAGACCCCAATGCTCCGAAGAGACCACCGTCTGCCTTCTTCCTGTTTTGCTCTGAAAATCGCCCAAA GATCAAAATTGAACACCCAGGCCTGTCTATTGGAGATACTGCGAAGAAACTGGGTGAGATGTGGTCTGAG CAATCTGCCAAAGATAAACAACCGTATGAGCAGAAAGCAGCTAAACTAAAGGAGAAGTATGAAAAGGATA TTGCTGCATACCGTGCCAAGGGCAAAAGTGAAGCAGGAAAGAAGGGTCCTGGTAGGCCAACAGGCTCAAA GAAGAAGAACGAACCAGAAGATGAGGAGGAGGAAGAAGAGGAGGAAGAGGAGGAAGATGACGAGGAAGAA GAGGAGGATGAAGAATAAGTGGCTGTCCTAAAGTGTGGAGTATATTTGCTCAGGCAATTATTTTGCTAAG AATGTGAAATTCAAGTGCAGCTCAACATTAGCTTCAGTATAAAAACTGTACAGATTTTTGTATAGCTGAT GAGATTCTTTGTAGAGAAAATACTTTTTAAGAAGAGTTTGTAGCTTTTTCAGGGGCTACAACTACAGTTA GATTTAAAGCTTTTGATGTTGAATGTTTCTAAATATTTAATGGTTTCTTTAATTTCTTATGCTAGCAAAA AAAAAACTTCATAGGAATTTGTATTACCAGTAAAAATTTTTTTTAGGATGTTGCATTTTTTTGTTTTTTT TTAAATTTGTAATAAAATAATGTATATTAAAAAAAAAAAAAAAA |
| Restriction Sites | RsrII-NotI |
| ACCN | NM_008252 |
| Insert Size | 633 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | BC083108, AAH83108 |
| RefSeq Size | 1094 bp |
| RefSeq ORF | 633 bp |
| Locus ID | 97165 |
| UniProt ID | P30681 |
| Gene Summary | Multifunctional protein with various roles in different cellular compartments. May act in a redox sensitive manner. In the nucleus is an abundant chromatin-associated non-histone protein involved in transcription, chromatin remodeling and V(D)J recombination and probably other processes. Binds DNA with a preference to non-canonical DNA structures such as single-stranded DNA. Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters by enhancing transcription factor binding and/or bringing distant regulatory sequences into close proximity (By similarity). Involved in V(D)J recombination by acting as a cofactor of the RAG complex: acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS) (PubMed:9184213). Proposed to be involved in the innate immune response to nucleic acids by acting as a cytoplasmic promiscuous immunogenic DNA/RNA sensor which cooperates with subsequent discriminative sensing by specific pattern recognition receptors (PubMed:19890330). In the extracellular compartment acts as a chemokine. Promotes proliferation and migration of endothelial cells implicating AGER/RAGE (By similarity). Has antimicrobial activity in gastrointestinal epithelial tissues (By similarity). Involved in inflammatory response to antigenic stimulus coupled with proinflammatory activity (PubMed:25306442). May play a role in germ cell differentiation (PubMed:11262228). Involved in modulation of neurogenesis probably by regulation of neural stem proliferation (PubMed:24391977). Involved in articular cartilage surface maintenance implicating LEF1 and the Wnt/beta-catenin pathway (PubMed:19805379).[UniProtKB/Swiss-Prot Function] Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All 4 variants encode the same protein. |
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| MR202266 | Hmgb2 (Myc-DDK-tagged) - Mouse high mobility group box 2 (Hmgb2) |
CNY 2090.00 |
|
| MR202266L3 | Lenti ORF clone of Hmgb2 (Myc-DDK-tagged) - Mouse high mobility group box 2 (Hmgb2) |
CNY 3990.00 |
|
| MR202266L4 | Lenti ORF clone of Hmgb2 (mGFP-tagged) - Mouse high mobility group box 2 (Hmgb2) |
CNY 3990.00 |
