Oas1a (NM_145211) Mouse Untagged Clone
CAT＃: MC202380
Oas1a (untagged) - Mouse 2'-5' oligoadenylate synthetase 1A (Oas1a), (10ug)
CNY 3656.00
Product images
Specifications
| Product Data | |
| Type | Mouse Untagged Clone |
| Tag | Tag Free |
| Synonyms | L3 |
| Vector | PCMV6-Kan/Neo |
| E. coli Selection | Kanamycin (25 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data |
>BC057878 sequence for NM_145211
GACTTAGCATGGAGCACGGACTCAGGAGCATCCCAGCCTGGACGCTGGACAAGTTCATAGAGGATTACCT CCTTCCCGACACCACCTTTGGTGCTGATGTCAAATCAGCCGTCAATGTCGTGTGTGATTTCCTGAAGGAG AGATGCTTCCAAGGTGCTGCCCACCCAGTGAGGGTCTCCAAGGTGGTGAAGGGTGGCTCCTCAGGCAAAG GCACCACACTCAAGGGCAAGTCAGACGCTGACCTGGTGGTGTTCCTTAACAATCTCACCAGCTTTGAGGA TCAGTTAAACCGACGGGGAGAGTTCATCAAGGAAATTAAGAAACAGCTGTACGAGGTTCAGCATGAGAGA CGTTTTAGAGTCAAGTTTGAGGTCCAGAGTTCATGGTGGCCCAACGCCCGGTCTCTGAGCTTCAAGCTGA GCGCCCCCCATCTGCATCAGGAGGTGGAGTTTGATGTGCTGCCAGCCTTTGATGTCCTGGGTCATGTTAA TACTTCCAGCAAGCCTGATCCCAGAATCTATGCCATCCTCATCGAGGAATGTACCTCCCTGGGGAAGGAT GGCGAGTTCTCTACCTGCTTCACGGAGCTCCAGCGGAACTTCCTGAAGCAGCGCCCAACCAAGCTGAAGA GTCTCATCCGCCTGGTCAAGCACTGGTACCAACTGTGTAAGGAGAAGCTGGGGAAGCCATTGCCTCCACA GTACGCCCTAGAGTTGCTCACTGTCTTTGCCTGGGAACAAGGGAATGGATGTTATGAGTTCAACACAGCC CAGGGCTTCCGGACCGTCTTGGAACTGGTCATCAATTATCAGCATCTTCGAATCTACTGGACAAAGTATT ATGACTTTCAACACCAGGAGGTCTCCAAATACCTGCACAGACAGCTCAGAAAAGCCAGGCCTGTGATCCT GGACCCAGCTGACCCAACAGGGAATGTGGCCGGTGGGAACCCAGAGGGCTGGAGGCGGTTGGCTGAAGAG GCTGATGTGTGGGTATGGTACCCATGTTTTATTAAAAAGGATGGTTCCCGAGTGAGCTCCTGGGATGTGC CGACGGTGGTTCCTGTACCTTTTGAGCAGGTAGAAGAGAACTGGACATGTATCCTGCTGTGAGCACAGCA GCACCTGCCCAGGAGACTGCTGGTCAGGGGCATTTGCTGCTCTGCTGCAGGCCCATGACCCAGTGAGGGA GGGCCCCACCTGGCATCAGACTCCGTGCTTCTGATGCCTGCCAGCCATGTTTGACTCCTGTCCAATCACA GCCAGCCTTCCTCAACAGATTCAGAAGGAGAGGAAAGAACACACGCTTGGTGTCCATCTGTCCACCTGTT GGAAGGTTCTGTCTGACAAAGTCTGATCAACAATAAACCACAGCAGGTGCCGTCAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAA |
| Restriction Sites | RsrII-NotI |
| ACCN | NM_145211 |
| Insert Size | 1104 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | BC057878, AAH57878 |
| RefSeq Size | 1430 bp |
| RefSeq ORF | 1104 bp |
| Locus ID | 246730 |
| UniProt ID | P11928 |
| Gene Summary | Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes higher oligomers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L.[UniProtKB/Swiss-Prot Function] |
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| MG220171 | Oas1a (tGFP-tagged) - Mouse 2'-5' oligoadenylate synthetase 1A (Oas1a), (10ug) |
CNY 3140.00 |
|
| MR220171 | Oas1a (Myc-DDK-tagged) - Mouse 2'-5' oligoadenylate synthetase 1A (Oas1a) |
CNY 3656.00 |
|
| MR220171L3 | Lenti ORF clone of Oas1a (Myc-DDK-tagged) - Mouse 2'-5' oligoadenylate synthetase 1A (Oas1a) |
CNY 4750.00 |
|
| MR220171L4 | Lenti ORF clone of Oas1a (mGFP-tagged) - Mouse 2'-5' oligoadenylate synthetase 1A (Oas1a) |
CNY 4750.00 |
