PLD6 (NM_178836) Human 3' UTR Clone

Specifications

Product Data
Product Name	PLD6 (NM_178836) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	ZUC
ACCN	NM_178836
Insert Size	1802 bp
Sequence Data	Insert Sequence (showhide) >SC216440 3’UTR clone of NM_178836 The sequence shown below is from the reference sequence of NM_178836. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC TGCGGCACCTCCAGCGAAAGCCAAACCTAACCAAGAATGGGGCTGAGCCCTCCCTGCGGGCTGCTGTGC GTTCTGAGGGAGGGAGACCTCGGCACTAGAAAAAAATCGTTAAACTAAAGTCTCGTCTATTAGAATACT AAATTGAACTAAAGAAGGTTAGGAAAGGGAAATTTCTGTTACTTCGGGTCAGTTATTTCGGGCCAGACC TTTTTCTTGCTCCTTTGCCAAAATAACTTCAGTCACGACCTGCCACGGGGTGCTTTCATGAGTGTGGTC CGTATCTTGGTTTGGAATCGAAACTTCTGCTACAGCACAGAAAAGGCACAGTGCCTCTTCCAGGTCGAT CCCATTCCCTTCCCTGATTCTAGAAAAGTCCCTCCTGCTTTGGCTGATGTGGGCCCTTTCAGCATCTCC CTGAGATTTCATCCCTCTCTCCATGTGGCACGACTGGGGTTGGTTGGGGCCTACAGTCTCCTTGTCCCT CACAGTCTGCCCCTGTCAGGGCTCGGTCCTCAGAGTAAGGAAAGGAAATGGAAGTCAGGAGGAAGGGAA GATGTGAGTGTGCGGTGCGGGTGGCAAAAGCAGCCTTCGGGGCAACCCCGTGAGCGTCATTGCCACCAA AGGCTGGCTGTTCCCTTGATTCCTTGCATAATTGCTCTTTAAAACCAGTATGCACGCCAGTGCCAAGCT CTTCAGCAGCCTGTCCTTGGGTAGTAAGTGCTGTGGTCTGTCAGGACTGATGGCCAGCAGCTGTTTCTA TGTTGGGCTTTTAACTTTTTTTATTTTATTTATTTATTTATTTATCTTTTTTGAGATGGAGTCTCACTC TGTGGCCCAGGCTGGAGTGCAGTGGCACAACCTCGGCTCACTGCATCCTCTGCCTCCTGGGTTCAAACG ATTGTCCTGCCTCAGCCTCCCGAGTAGCTGGGATTACAGGTGCCTGCCACAACACCTGGCTGATTTTTT TTTTGGTATTTTTAGTAGAGACAGGGTTTCACCATGTTGGTTAGGCTGGTCTCAAACTCCTGACCTCAA GTGATCCACCACTTCCGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCGCCATGCCCGGCCGGGCTT TTAACTTTTAATGTCCTAATGTTAAGGTAATTTTGTTGTGTGTTTAGAAGTGACCTTACCTTTAACACC TGTGGAGTTAGTGCGTGCACATTGCTGGCTCAGCGTAACCCATCACGGGACCGGAGGAGAGGAGAGCGG GGAAGAGGAGAGCAGCTTCAGGCCGTGGTGTCTCCCACGTCTGTGTTCTTATTTGCAGCTCAGGGTTTG CATTCCCAGGTAGAACAGGTGTCGTACACTGTGAAATGTTCCAGGTTATTTGTTTATAATGTGTGTGTC ATATACAGATAGCTCCGATGACATCTGAAGTTGTGACTTCATCATCTTGTCATATTTCTGTATGATGAG CCCCAGGGCCCATCCTGAGGTCTGCTAGCCATGTGCTTAGTCTCACCTCCCCAGCCCACGCTGGCATTA CCACCCAGAGACCCTTCAGTGCTGTGTGTTTTTCCTTTTTAGGGTTACTTTTGACTCACAGTGTTAGGC AAGCCAGCTTGGAAGTTAACTTTTAAAAAAATTCAATTGAAGCTGTAAAGTATAATATATAGATTGGAA GTCACCAGAAATTGTTTTAGTTTGTGAATTCCCCCAGTGTATGTTCTGAAAAGAAAATGGGAGAGCTTG TAAAGCATCTCCTAAATGCGAAGCCGCGTGACCCTGGACTTCTGGCACATCTGAATAAACATGTTCTTA TTCTGGAA ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_178836.4
Synonyms	ZUC
Summary	Endonuclease that plays a critical role in PIWI-interacting RNA (piRNA) biogenesis during spermatogenesis. piRNAs provide essential protection against the activity of mobile genetic elements (By similarity). piRNA-mediated transposon silencing is thus critical for maintaining genome stability, in particular in germline cells when transposons are mobilized as a consequence of wide-spread genomic demethylation (By similarity). Has been proposed to act as a cardiolipin hydrolase to generate phosphatidic acid at mitochondrial surface (By similarity). Although it cannot be excluded that it can act as a phospholipase in some circumstances, it should be noted that cardiolipin hydrolase activity is either undetectable in vitro, or very low (PubMed:21397848). In addition, cardiolipin is almost exclusively found on the inner mitochondrial membrane, while PLD6 localizes to the outer mitochondrial membrane, facing the cytosol (PubMed:21397848). Has been shown to be a backbone-non-specific, single strand-specific nuclease, cleaving either RNA or DNA substrates with similar affinity. Produces 5' phosphate and 3' hydroxyl termini, suggesting it could directly participate in the processing of primary piRNA transcripts (By similarity). Also acts as a regulator of mitochondrial shape through facilitating mitochondrial fusion (PubMed:17028579, PubMed:26711011).[UniProtKB/Swiss-Prot Function]
Locus ID	201164
MW	68.2

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.