SH2D1A (NM_001114937) Human 3' UTR Clone

Specifications

Product Data
Product Name	SH2D1A (NM_001114937) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	DSHP; EBVS; IMD5; LYP; MTCP1; SAP; SAP/SH2D1A; XLP; XLPD; XLPD1
ACCN	NM_001114937
Insert Size	1799 bp
Sequence Data	Insert Sequence (showhide) >SC216406 3’UTR clone of NM_001114937 The sequence shown below is from the reference sequence of NM_001114937. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC GATCCTGATGTCTGCCTGAAAGCCCCATGAAGAAAAATAAAACACCTTGTACTTTATTTTCTATAATTT AAATATATGCTAAGTCTTATATATTGTAGATAATACAGTTCGGTGAGCTACAAATGCATTTCTAAAGCC ATTGTAGTCCTGTAATGGAAGCATCTAGCATGTCGTCAAAGCTGAAATGGACTTTTGTACATAGTGAGG AGCTTTGAAACGAGGATTGGGAAAAAGTAATTCCGTAGGTTATTTTCAGTTATTATATTTACAAATGGG AAACAAAAGGATAATGAATACTTTATAAAGGATTAATGTCAATTCTTGCCAAATATAAATAAAAATAAT CCTCAGTTTTTGTGAAAAGCTCCATTTTTAGTGAAATATTATTTTATAGCTACTAATTTTAAAATGTCT TGCTTGATTGTATGGTGGGAAGTTGGCTGGTGTCCCTTGTCTTTGCCAAGTTCTCCACTAGCTATGGTG TCATAGGCTCTTTTGGGATTTTTGAAGCTGTATACTGTGTGCTAAAACAAGCACTAAACAAAGAGTGAA GGATTTATGTTTAATTCTGAAAGCAACCTTCTTGCCTAGTGTTCTGATATTGGACAGTAAAATCCACAG ACCAACCTGGAGTTGAAAATCTTATAATTTAAAATATGCTCTAAACATGTTTATCGTATTTGATGCTAC AGGATTTGAAATTGTATTACAAATCCAATGAAATGAGTTTTTCTTTTCATTTACCTCTGCCCCAGTTGT TTCTACTACATGGAAGACCTCATTTTGAAGGGAAATTTCAGCAGCTGCAGCTCATGAGTAACTGATTTG TAACAAGCCTCCTTTTAAAGTAACCCTACAAAACCACTGGAAAGTTTATGGTTGTATTATTTTTTAAAA AAATTCCAAGTGATTGAAACCTACACGAGATACAGAATTTTATGCGGCATTTTCTTCTCACATTTATAT TTTTGTGATTTTGTGATTGATTATATGTCACTTTGCTACAGGGCTCACAGAATTCATTCACTCAACAAA CATAATAGGGCGCTGAGGGCATAGAAGTAAAAACACCTGGTCCCTGCTCTCAGTTCACTGTCTTGTTGG ACGAGAAAACAATAACGATAAAAGACAGTGAAAGAAAATAACGATAAAAGACAGTGAAAGAAAATAACA ATAAAAGACAAGGAAAAAATAACAATGAAAGTTGATAAGTACATGATAAGCGAGGTTCCCCGTGTGTAG GTAGATCTGGTCTTTAGAGGCAGATAGATAGGTCAGTGCAAATACTCTGGTCCATGGGCCATATGAAAA GGCTAAGCTTCACTGTAAAATAATAACTGGGAATTCTGGATTGTGTATGGGTGTTGGTGAACTTGGTTT TAATTAGTGAACTGCTGAGAGACAGAGCTATTCTCCATGTACTGGCAAGACCTGATTTCTGAGCATTTA ATATGGATGCCGTGGGAGTACAAAAGTGGAGTGTGGCCTGAGTAATGCATTATGGGTGGTTTACCATTT CTTGAGGTAAAAGCATCACATGAACTTGTAAAGGAATTTAAAAATCCTACTTTCATAATAAGTTGCATA GGTTTAATAATTTTTAATTATATGGCTTGAGTTTAAATTGTAATAGGCGTAACTAATTTTAACTCTATA ATGTGTTCATTCTGGAATAATCCTAAACATATGAATTATGTTTGCATGTTCACTTCCAAGAGCCTTTTT TTGAAAAAAAGCTTTTTTTGAATCATCAAGTCTTTCACATTTAAATAAAGTGTTTGAAAGCTTTATTTA CCTAA ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_001114937.3
Synonyms	DSHP; EBVS; IMD5; LYP; MTCP1; SAP; SAP/SH2D1A; XLP; XLPD; XLPD1
Summary	This gene encodes a protein that plays a major role in the bidirectional stimulation of T and B cells. This protein contains an SH2 domain and a short tail. It associates with the signaling lymphocyte-activation molecule, thereby acting as an inhibitor of this transmembrane protein by blocking the recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to its docking site. This protein can also bind to other related surface molecules that are expressed on activated T, B and NK cells, thereby modifying signal transduction pathways in these cells. Mutations in this gene cause lymphoproliferative syndrome X-linked type 1 or Duncan disease, a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus, with symptoms including severe mononucleosis and malignant lymphoma. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Locus ID	4068
MW	70.7

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