KLHL25 (NM_022480) Human 3' UTR Clone

Specifications

Product Data
Product Name	KLHL25 (NM_022480) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	ENC-2; ENC2
ACCN	NM_022480
Insert Size	1740 bp
Sequence Data	Insert Sequence (showhide) >SC216125 3’UTR clone of NM_022480 The sequence shown below is from the reference sequence of NM_022480. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC GTCAGCACCTGGAAGCACCTGCCCGCGTGAGGAGCACCTGCTGAGCCCAGCCAGACCGCGGCCTTCAGT GTCACAGCGTGGCCTTGCTTGTCTGCCACAGCGGGAGCTAAGCCGGCCCTGGGCCAGCACTCCGAGAGG TGGAAGGGGCCCTGCCAGCTCTGGGGAGCAGCAGCCTTGGGCTGTTCTGAGCTTTAGGCAAGAGAAGAG AAGCATCTCTTGCATCCGTGCCCCTGGGGGCCTCTTCAGCTTTGCAGTGGTTTGTGGGAAGACATACCT CCCAGAGGGGCATGGACTGCCACCAGGACTGACCCTGGCGTCGGGGAGAAGGACACTTGCAGAGCCTTG AGATCACCTGTTTGGCAGGTCCTGGACTGGGGCCGGGCAGGCAGGGGCAGGGAGGCGCCCCGGGTGGGC TTTGGGGCTGCGGCACTGCCACACATCCTTTCCCTCCTGGCCTGCCCTGCTGGGGCTCTACTGCCATCT ATAGATGGTGTCCTGGGCCTGGGAAACTAGGTTCCCAGGGGTTGAGACCAGAAAGGTGACCAAGACAGA TTTTTTAAGGTGCAGAAACTGCAGGGGGGCCTCAGTGACATCCATGAGGCCTTATTAGCAAAGGACACC CAGACCTCCAAGGTTTGTGGGCCCCTTCCACAAAGCTGTAAGTCCCAGCCCACCTACTCAGGGCCTTGC TCAGTGCTGTGGCCCGGTGGGGACACAGTTGCTCGTGGCCACTCAGTGGAGCTGGGCCTGCAGCAGACT CAAGGCTCCGAGTGCCCTGGGGGTCACCCCTCCCCTCCCCTCCTCAGAGCCCACCCTGAGAGGCAGCAG TGACCCCCATGGCACACACCTGCCAACAGCACTGGGGGCTTCTCCCCAGGAGACCACGCTGCCCTCCAA GACCAGGAGCAGCTGTGAGCTGGAGACAGCAGAGGGACCCCAGGGTGTCCCCTGCAGATCCCACCAGGG CCGCATCCATCTCAGTGTGGAGGACAGTGACGGGACCCTCACCATCCTCTTGCGTTTTGGCCCCCATTT GCTCCCTGAGCTCCAAGATAAGAATGGCCCCGAGAGAACTGCTGAACATTTGTTCATTGCTGTCACCTC CTGAGTCACTGGGGTCCCTCACCAGCACCTCCCTGACACCTGGGCTATGGAGAGGTTGGCGCCTGTCAG TGACCATCCTAATGCCTCTCGCTCACTCCCAAGCCACCATTTGAGAGGGAGGGGTGTTGGTGCCCTGAC AGGGACTGGGCAGGGTGTCCAAACTTGGGGCTTCCCAGGCACCTGCAGTGTGAACACTGCTTGGCTGGC TCAAGATTAGGGCCGCGGAGGGGGCTGTGCACATACCAGTTACTTAAGCAGCCACGAGTGTCCCCCATG CCTTGGTGCGGGTCCTGGAGGCCTCTTGGGGGTGGGACCTTTGGGCAGGGTTTGCCCACTGACACGCCC GCCATGGGGCACTGGCTGCATGGGGCTCCTTGGACCCTGTAGACCCAGCAGACCCCGCCTGTGTCAGGC CAGCTGCCCGAAGGCACTTGGCTGTGGTCCCAGGGGACGGCTCTGCTGGCACACTCAGGAGCCTGGCCG CGGGGACTGCAGGGAGGGTGCCTGGACCCGTGGGGTTGCTTCATTGAGATAAAGCACACTTATCACATA GCACAAAGGACGTGCCATGGTGCTTTCCCCAAAAGTTGTGTTGCTTTTATCAGTTTTCTAACTTAATAA AAAGAGTTGAGAAAA ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_022480.4
Synonyms	ENC-2; ENC2
Summary	Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1): ubiquitination and subsequent degradation of hypophosphorylated EIF4EBP1 (4E-BP1) probably serves as a homeostatic mechanism to maintain translation and prevent eIF4E inhibition when eIF4E levels are low. The BCR(KLHL25) complex does not target EIF4EBP1 (4E-BP1) when it is hyperphosphorylated or associated with eIF4E.[UniProtKB/Swiss-Prot Function]
Locus ID	64410
MW	62.4

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