Influenza Virus NS1A Binding Protein (IVNS1ABP) (NM_006469) Human 3' UTR Clone

Specifications

Product Data
Product Name	Influenza Virus NS1A Binding Protein (IVNS1ABP) (NM_006469) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	ARA3; FLARA3; HSPC068; IMD70; KLHL39; ND1; NS-1; NS1-BP; NS1BP
ACCN	NM_006469
Insert Size	1677 bp
Sequence Data	Insert Sequence (showhide) >SC215833 3’UTR clone of NM_006469 The sequence shown below is from the reference sequence of NM_006469. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC AGCCCCTATACAAAGATTTTCCAGTTTTAACAAATTTAAGACCCTCTCAAACTAACAGGCTTAGTGATG TAATTATGGTTAGTAGAGGTACACTTGTGAATAAAGAGGGTGGGTGGGTATAGATGTTGCTAACAGCAA CACAAAGCTTTTGCATATTGCATACTATTAAACATGCTGTACATACTTTTTGGGTTTATTTGGAAAGGA ATGCAAAGATGAAGGTCTGTTTTGTGTACTTTTAAGACTTTGGTTATTTTACTTTTTGGAAAAGAATAA ACCAAGAATTGATTGGGCACATCATTTCAAGAAGTCCCCTCTCCTCCACATTTGTTTTGCCAATTTGCA CATTAAATGACTCTTCCCTCAAATGTGTACTATGGGGTAAAAGGGGTAGGGTTTAAAGATGTAGACAGT TGGGTTTTTTAAGGGCCCTTTTTCAATAACTGGAACACTCTATAACAAAGGATACTTATTTAAATAGAT GACATTGACTATTTTTGTTTTTATTAAAAGGAAGCTTACATGCCTACCAATATTTAATCTTTTATGATT GCCTTTTTATAACTTTTTATATTCTCAGCAGAGTGCTTTACCAATTGAAGTAAAATGTGGCAGGCTGGA GTTATTGAAGCAGAGTGGCAGTCTTCAGTTTGCAGAGTAGGGGTCTGTCTTTTAAACTCTGAGTGCAAA CTTCAGAGTTCTTGCCTTGGCTGCAGTTTTTTTCCTTCAAGAATGCAGTACTAACATTTATTTGAGTGG AGTTACTGAACAGTAACATAGCTGTGATTTTTGGTATTTGAAACACTGGTTTTAAATATTTTGACTTGT TGAGGGTATGTTTTATATAGCAAGACATTATATAGCAGTAAAAAATGGTGTTTTATCTTCTATATAATT CCTGTTTTTATTATTAACAAAACAGTCCTAAATAGCAGCCCTCAATTGTGAAAAAATTTACTTTAAACT ACATTAGGTTGTGAATGCAGGTTTTATCAGAACTATGTTTTTGTTCAGTTTATCTGTTCATATGGATAA ATATTGGTTGGGATGACTTGGTGTCTAATGTGTAGTGCTACACACCTAACTTATGGGGCCAAAATAGCA TGTCCTAATGCTTGCTGCTGATTTAAACACATTAAAGGTACTTTGCAGGAAATCCTTGCACCATGGGAT TAATATCCAATTGCTGCTTGTACACTCATTCATTACTAAAAGTTTTGAGAAATTTTTTTTTCCAGTAAT GAGCTTAAGAAATTTGTGGAAAATAACTCACCTGGCATCTTACATCTGAAATAAGGAATGATATAAGGT TTTTTTTTCTCACAGAAGATGAAGCACACAGGAACCTAATGGGCCAACTGGGATGAGGTGACTATTCTG AGATGACTATTCAGTGGCTAACTTGGGTTAGGAAGAAAATAATTAGGTATTTTCTCCAAATGTTCACTG GTACTCTGCCACTTTATTTCTCTCATCTGTTACACAAAGAACCACCAGGAAAGCAAATCAGTTTGGTTG GTAACTCTGTAATTCCTAACTATCACTGGTTTGGTTCTGGACTAAAACTACATTGACAGATTGAATTTG CCTAATATGATGACTGTTTTTAATATGGATCTGTATGTGTTCTATTCAGCACAAGGAAATAAAATTTTA GTTGAGGATTCAGCACTAAAA ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_006469.5
Synonyms	ARA3; FLARA3; HSPC068; IMD70; KLHL39; ND1; NS-1; NS1-BP; NS1BP
Summary	Involved in many cell functions, including pre-mRNA splicing, the aryl hydrocarbon receptor (AHR) pathway, F-actin organization and protein ubiquitination. Plays a role in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through Kelch repeats (By similarity). Protects cells from cell death induced by actin destabilization (By similarity). Functions as modifier of the AHR/Aryl hydrocarbon receptor pathway increasing the concentration of AHR available to activate transcription (PubMed:16582008). In addition, functions as a negative regulator of BCR(KLHL20) E3 ubiquitin ligase complex to prevent ubiquitin-mediated proteolysis of PML and DAPK1, two tumor suppressors (PubMed:25619834). Inhibits pre-mRNA splicing (in vitro) (PubMed:9696811).[UniProtKB/Swiss-Prot Function]
Locus ID	10625
MW	64.6

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