HSBP1 (NM_001537) Human 3' UTR Clone

Specifications

Product Data
Product Name	HSBP1 (NM_001537) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	NPC-A-13
ACCN	NM_001537
Insert Size	2000 bp
Sequence Data	Insert Sequence (showhide) >SC215535 3’UTR clone of NM_001537 The sequence shown below is from the reference sequence of NM_001537. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC AACAAGATACCTGCCACGCAAAAGAGTTGAAGGTTGCTAATAATTTATACTGGAATCTGGCATTTTTCC AAGCCAAGAGAAGATCGAATGGCTTTTTGCAGCTAACTACTATGTGTAGACAGGTTTTATATTATAAAG TATGCATTCTTATCACCTAGTATATAGTTAGTTTGTAGAGTGATTTCCCCCCAGTTTCTTGAACATGGT ATCTTCACATCTTGGACCTTGGTCAGTTGTGCTATTCATTATTAAACACTAAAACTTTGGCGGTTCTTG CATAACATTGTCAGATTTTTTAGTGTATTTCTGTGAAGTCATTTTTTTTCTTGTCATTCCTTTTGTAGT AGTTGCTGTTTGGATAAAAGTTGATGTGTGATTTTTTATTAAACAAATAGTAAACCCTTCAATTATAGT TAGTCTTGGTGAAGTAAGATGTTTGTAGACTTTAGAGTTCTTTAATTCTTGGCACAACGTGACTGTTGA GCTAACACCAAATAGTGTGTTGGCAATACTTTTCAAATGGCTGAAAACACCTAAAAATTGTTCATTCAG AAATATCTGTCACTGCTCTGTTGCCAAAACTCAGAATAGAACTTAGACGTATGTCTGAGTCCCTGAGAT CACATGCTAAAGTCGATGAAAAGTAACCACTGCCACTGTCTTGTGTCAGAACTTTTACAGTACAGAAAA TAACAGAATAGCCTTCTGTAATGAGGCGTTTGTTAGAGTTTTGCATGAGATTCTAATACTTCAGTAGGA CCCTACCTACGTGGTTCATCTACAATGGTTACCATAAAAAATCTGGCAGGATTTTAAAACTCAATCAGT CTTTCCTTTGAGCTAGTGACTTGAAAAGAAAGAGAGAAGGAAAAGAGACCATATTAAGTCCATGCCAGT TGCTTGGCTAGAATATGATCAACGACTTGTAGTAGACTCAAGTTTTTAAAAAACACTATTTTACTTAAA CTGTTTCTTATCTAAATTCTTGCAGAGTGTCAATGTTATCATTGATTATAGAAGACAGGGATAATACCT TTATCTCTGGCCACTCAAAAATGCAGTGCCAGGAGTGCTAAACCTAGAGGCCAATACTGATGACCTGGA AGGTGATCCATATGATTGTCACCACAAAGTGCTTTTACACAAAAACTTGAAAATTTGAAAAACATGATT TTTTTAAGTTTCTCATCTCACCAGTCTTGGTGTTTATATTGCAAATCTATCAAAGTAAGAAATAATTTG TGCTGTATACAAATTACATGGGGAACATAAAGGAGTGAGATCCTTCTGTGATAAAATGAATTCACCACT CTGGTTACCCAACTACAGAACCTCCTTTGATCAGGCCAGTAGGTTGTGATGCAGGCTGGAGCCCCCGAA TGCCCCACACACACTGCAGCATTGACCAGACCATCCGAAACCTGCGTCCCTGGTGATGTTCTCAAGCCT CGGAAGTGGCAAATGGAAATGATATGGCCGGTTGCGGTTGTAGGAGAGTTGTGACTTAGGCAGGAGTCG ACCTCCTCAAGTAATGGAACGATTTCAAAGGCAGGCTGCCCTGACCAAAAATATCTGCCATGAATAAAG GTGCCTGAAATCCTGCTATGAAGCTTCCTTTGTGTCAAAAATCTGTTTGGTTTTCAGATGGAAATGCAG AAATCACATTAGAGTATCAACTAAAACCTCTGGACGGATTAAGTACAAGTAGCCCAAGGCAAAGCAGGA GAGGGGGTGTTGGGGGAGGTTGCCTGCTGGAAGGGGAAGCTGAGGAGCGGGAGGAGGGCTTGCCAAGAC TGGCATTGCAGGAGACTTGTCTCAGGTGTGTTCCCAGAACTCTTGCCCCTGGAGATGCTGCAGGAAGGA AGGGGTTATGGTCACTTGGGTTTAGACGACATTCTGTGAACCTCATGAAGAAATTAGCATATTAAAGAC TCTGAAAGTAGAGCAGAGAACTCAGCTTTAACCTGCTCACCTGCTAGTTTTCGAGGTCTCGCTCTGTT ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_001537.4
Synonyms	NPC-A-13
Summary	The heat-shock response is elicited by exposure of cells to thermal and chemical stress and through the activation of HSFs (heat shock factors) results in the elevated expression of heat-shock induced genes. Heat shock factor binding protein 1 (HSBP1), is a 76-amino-acid protein that binds to heat shock factor 1(HSF1), which is a transcription factor involved in the HS response. During HS response, HSF1 undergoes conformational transition from an inert non-DNA-binding monomer to active functional trimers. HSBP1 is nuclear-localized and interacts with the active trimeric state of HSF1 to negatively regulate HSF1 DNA-binding activity. Overexpression of HSBP1 in mammalian cells represses the transactivation activity of HSF1. When overexpressed in C.elegans HSBP1 has severe effects on survival of the animals after thermal and chemical stress consistent with a role of HSBP1 as a negative regulator of heat shock response. [provided by RefSeq, Jul 2008]
Locus ID	3281
MW	75.6

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