SPSB4 (NM_080862) Human 3' UTR Clone

Specifications

Product Data
Product Name	SPSB4 (NM_080862) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	SSB-4; SSB4
ACCN	NM_080862
Insert Size	1372 bp
Sequence Data	Insert Sequence (showhide) >SC214254 3’UTR clone of NM_080862 The sequence shown below is from the reference sequence of NM_080862. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC TCTCTCAAAAACTATCTGCAGTACCAGTGAGCCAAGCCTGATGGGCAGCACAGACACAGACACACACCG CAGGGCCCGACCCTCCTGTCATTCACAGTCCCATGGCACATAGGGGAAAGGATCTACCCTTCTCCTGGC TCCCCAGGACACTCAGTTCTTTCAAAGACCAGGATGTGGTACCAACTTTGGAAACGAAAGGTCTCTTGC CAACAGTATCTACTGCCCTCGAGGCAGCCCTCCCAAGTCAGACACCTCCTTCGGAGCCACAGAGAGCCT GGAGTCTGCACCTCCTGGAAATCCTGCCACCAACCAGGACACAGCAGCCACCGTATTGATCAGAGAGCC TGTTTCCTTATTCAAGAGAATGAATAAAACATTTAGGCAGGAGACTTTCTATTGTGTGCCCCGTTGCAG ACAGGGCCAGGGAGAAATTAGCCAGTGCAGGGGGAAAATTGCCTCTGAATAATGAATGATGAAAGCCTG ACGCCGTGCCCCTCCTGGCCCATACGCCTTGCCAGGGCGGCAGGATTGTCACACCGTTTTAGGACTCTG TGCCACTTTGAGAGACTGTTCCCAGGAGGCCCAACCGCAGACCTGGCAAGTGGACAGTGCAGTGTGGAG ACACCTTCCGGCTTACCTCTTTGAACGTTGTTTACCTACCCCTTTCCACGTGCTCCCCTTCCCAGCCAC TGACTCACAGTTCTCTGGATGCCCAGACACCTCTCTTCAGGGAAGATGAGTCTGACTGGTTTGCCCCAG GGAAGAGCATATCCTTACCATTATTTTAAGTAGCATTTGCATTTTAAAAGAGGAATGCGGAGAGGACAG TACTTAGTCCAAAGGTGCTAACGGGGGAACTGGGGGCATTGTGACACCCAAGTCTGATGTGTCCTGGGT TGGGGGGCCTTCCTGGAGTGTCAGGGTCTCTGGGCAACGTCCATTCAGGGTGCGGCATGGCTGTCACAA AGCTTTATTTGAGCAAATTATTTTTTCACTTTAGGAGACTTCTACAAGTTTGTTTCCTGTTTCAAATGT GTGTGTGATGTGCTGTTTATTTATCAGCTTGAGGTCCATGGGGGCAGCCTTGTGACTGGAAGGGTGGAT ATGGGAGACACATTCTCTACCTGCTCCGAGCCTGGTCCTCTCGCAGGAATGCTGCTGCTGCCTCCGCCG CCACTGCTGCTGCCACCTCTTATATGTTTCAGACACTCTCTGCCCAGACTCATTTTTAACTGGAAATCA TCACAGCAGTGGGATATCAGAGCCCCAGACAGCACTGCCTCTTCCTCCCCACCCCACTGCCCCCACCTT AATGTGAATTTGACTGATGAATGAAGAGCGTTTCTAATAAAGTTTGTCATTCAGTCCTTCA ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_080862.3
Synonyms	SSB-4; SSB4
Summary	Substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:21199876, PubMed:15601820). Negatively regulates nitric oxide (NO) production and limits cellular toxicity in activated macrophages by mediating the ubiquitination and proteasomal degradation of NOS2 (PubMed:21199876). Acts as a bridge which links NOS2 with the ECS E3 ubiquitin ligase complex components ELOC and CUL5 (PubMed:21199876). Diminishes EphB2-dependent cell repulsive responses by mediating the ubiquitination and degradation of EphB2/CTF2 (PubMed:28931592). Regulates cellular clock function by mediating the ubiquitin/proteasome-dependent degradation of the circadian transcriptional repressor NR1D1 (PubMed:26392558).[UniProtKB/Swiss-Prot Function]
Locus ID	92369
MW	51.8

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