USP20 (NM_001008563) Human 3' UTR Clone

Specifications

Product Data
Product Name	USP20 (NM_001008563) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	hVDU2; LSFR3A; VDU2
ACCN	NM_001008563
Insert Size	1408 bp
Sequence Data	Insert Sequence (showhide) >SC214247 3’UTR clone of NM_001008563 The sequence shown below is from the reference sequence of NM_001008563. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC AAGATCGAAGCCGAGACGCGGGCCGTGTGATCTGCTGGGCTAGTCTCCCCATGTGCCCCACCCCGCGGA AGGCGTGTTTGTGCCCAGAAGAGAGGCCGGGCTGCTGCAGAACCCCGCCGTGTAAAGAGGCAGAAAAGT TGGTTTGGTTTGCAGTAACGCTGCAACTAGAAAATATATGCACTTCAGGCTTGTTGAAACGACCAAGAC TCTGTGACGTTAATTTGGGTCTTTGTCCTGGCAGTGCCTCTGCCAGTCACTGTCATCGTTGTGTCCCCC ACAACTGTCCTCTTGCTAGCTCGGCCCAGCTTTGTCCCTGGAGCCCGATGCTACCCCTGTCAGACAGAG GCTGCGGCCTGGGCCAGAGTCAGGGAGTAGCTGCTGCTTCACGGCGTCTCCACTGTGCGATTGGCCCGG AGCCCCGAAGACTCGGAGGGAGCTGCTCAGGGCCGGTGAGCGCAGCCAGAAGCCCTGGCCAGTGAGGAG CTCACAGGTCCTCCCTGGTGGTCCCGCCGCACCTCTGCATCTCCTGGGCGTCACCAGGAAGGCTCTGAA GTCCCGGGCTGCTCTCAGCACTTCTCCTGCAGACTGAAGACTCTGGACTCATTGCTGATTGGAACACCA GGAGGAGGTTGGATTTCTGCCAGTGGGGGATGTTTCTGGAGGCAGCTGGTCCCCCACACCGCGTCCTGC TGAGCCTGCCCCCTGGATTGGCTGTAATTTGCCTCGAAGTTCAGCAGTTCATCTTCATGGGAAATTTGC TGAGCCCCCACCAGGGAACCGGATGATGAAACAGGGATACCTCACAGCTTGGCCATTTGAGGCAAAGGC AGCTTCCCGAGCTGATGCTAAAGAAGACAGACTTTCCCTTCCTCCCAGCAGCAGCAGTGCAGAGCCCAC CTGGAGGGATGTGGGGGCTGTGCAGGGTGCAGCGCTCAGGTGGATCCTGGGAAGCAGCCTCTGGATGCT GAGTGGAGGGAGCCACTGAGCACAGCAAGGCACCAAAGCCCCTGGAGAAACCGCCAGGGCGAGGTGCGA CCATCATCAGGATCAAAGCAGACGGGGCGTGGGTGGGGAAGGGGCTCTGGGACCAGACCCCCCACACTA CTGCGTCTTTGTTTCTATCAGTCTTTGTAGAAGCAGGTGGTGGTGGAAATTCCAGCAGGTGGGTCCCGC AGAGGCCCTGAGGCCTCACTTTTCGGATCTTCTGTCCCAGATCCTGCTCCCTCCCTGCTGAGCCTGGGG TTCCCCTGGCATTGGCCCCAGCCTTCTGAAAGCCGGCGCTGCAGCCAGAGGCCGCACGCTGCACTGTCG CGACGCAGAGAGGCTTCTGTGCAGGCTGGGATCGGGCCCCATGTCTGTGCTGTCTAGTTTGTGTTCAAA ATGTCAGAATAAACACAGAATAAATGTT ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_001008563.5
Synonyms	hVDU2; LSFR3A; VDU2
Summary	This gene encodes a ubiquitin specific processing protease that was first identified as a substrate of the VHL (von Hippel-Lindau disease) protein E3 ubiquitin ligase complex. In addition to being ubiquitinated by the VHL-E3 ligase complex, this enzyme deubiquitinates hypoxia-inducible factor (HIF)-1 alpha and thereby causes increased expression of HIF-1alpha targeted genes which play a role in angiogenesis, glucose metabolism, cell proliferation and metastasis. The enzyme encoded by this gene also regulates G-protein coupled receptor signaling by mediating the deubiquitination of beta-2 adrenergic receptor (ADRB2). This enzyme is a ubiquitously expressed thiolester hydrolase. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jan 2013]
Locus ID	10868
MW	51

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