DNA Ligase IV (LIG4) (NM_206937) Human 3' UTR Clone

Specifications

Product Data
Product Name	DNA Ligase IV (LIG4) (NM_206937) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	LIG4S
ACCN	NM_206937
Insert Size	1121 bp
Sequence Data	Insert Sequence (showhide) >SC212470 3’UTR clone of NM_206937 The sequence shown below is from the reference sequence of NM_206937. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC TTACAAGAAGAAAACCAGTATTTGATTTAAAGCTAGGTTTCCTAGTGAGGAAAGCCTCTGATCTGGCAG ACTCATTGCAGCAGGTGGTAATGATAAAATACTAAACTACATTTTATTTTTGTATCTTAAAAATCTATG CCTAAAAAGTATCATTACATATAGGAAAACAATAATTTTAACTTTTAAGGTTGAAAAGACAATAGCCCA AAGCCAAGAAAGAAAAATTATCTTGAATGTAGTATTCAATGATTTTTTATGATCAAGGTGAAATAAACA GTCTAAAGAAGAGGTGTTTTTATAATATCCATATAGAAATCTAGAATTTTTACTTAGATACTAATAAAA TACATTTAGAAACTTTTAAAGTCATGAAAAAGCATTAACCTTCTAAACAGTATATTCTAAAAAGTCAAA ACGTTAACAATAGTTTTTATCTAATAAAAGCACTGCAAGAAAATAGGGTAGAATTGTTACAGCTGGACT TGTAAAAATATGTCTTTTTACTCAGGGTTTAAAATGTCCCATTTAAATATGAAATGTAAACAAATTTGT TTTTTAAGGTTAAGGCCAAATGTAACAATAAAACCCTGTCGATGGTTTTAGCTAAATTAGAGGAAGTTG TATGAGACTTAATGATCTAAAAACTTAAAATTGAATTGGTTTGATTAAAAATAAAGCTTGCAATTTTAA AAGTAGCTCACATTTAATTTCTTGTGTGAAATAGAACATGCTTTAAAGGAAGTATTTTTATGTGAATTT GCATTCCAGTATAAATAGTATTCACAAAAAAGATTTTCCTAGATTTTATCTATTGAATAGGTGTCAATA TGGCATGCATATTGTAACTTTCATTAGAAATAAGTTGCTTTGACTTTTAAAAATGACATAGTTAGATTA TTTAAAGTCAATGTATATAGTATATATTATGTATGGATTTATATACCAAATTTTGGAATACAGCCTATC TCATGACCATATTGAAATGTACGGAATTTGATCCATGCGATACTATGTGTGCATTATTTGAAAGTTATT GGAAATTTTATTCAAACCGTGGAACAAATGTATGTGATTTTGTTATACTTCTTAATTTAAATAAAATAT TTAATGCACTATTAAAA ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_206937.2
Synonyms	LIG4S
Summary	The protein encoded by this gene is a DNA ligase that joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. This protein is essential for V(D)J recombination and DNA double-strand break (DSB) repair through nonhomologous end joining (NHEJ). This protein forms a complex with the X-ray repair cross complementing protein 4 (XRCC4), and further interacts with the DNA-dependent protein kinase (DNA-PK). Both XRCC4 and DNA-PK are known to be required for NHEJ. The crystal structure of the complex formed by this protein and XRCC4 has been resolved. Defects in this gene are the cause of LIG4 syndrome. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008]
Locus ID	3981
MW	44.8

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