RFTN1 (NM_015150) Human 3' UTR Clone

Specifications

Product Data
Product Name	RFTN1 (NM_015150) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	MIG2; PIB10; PIG9; RAFTLIN
ACCN	NM_015150
Insert Size	1013 bp
Sequence Data	Insert Sequence (showhide) >SC211798 3’UTR clone of NM_015150 The sequence shown below is from the reference sequence of NM_015150. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC AGAGAGCTTGGTACGGTTGAAGAAAACTGAGTCTTGGGCAATTTGTGCTAAAACTAGGTGAGTTGCCAA ACCCAAGGCATCTTACCAACAGCTGGTTTGGGGGCTGGTTTCCCTGGTGTTGTGTGTTACCTACCCTTT GGCTTGGCTTGACCTCTCCTTGTGAGCTCACCTGAGCCCTCCCAGGGCCAGGTTCCTGACAGTGTTGGT TTTTGCACATCCACTGGAAAGGTGTCATTAATGACCCAGTGTTAGAATGCAAGAGGTCAGGTTATTCTA GCCCTCATGGCTGAAGGCCCAGTCCTGGCTCCACCACTCCTCCAGCCAGAGGGTCTGGACCATCCAGTG CCTGTCCTCGCCACAGGGCCTCCAGGGAGCATTCGGGTCAAATCCATGGACACCCTGGGCTACAAACCA AGGCTGCTGTTCATCCCACATCGTGTGGGGCAGTGTCCATCCCCTGCAGCTACTTGGTGACTTAACAAC TCCAGGAGCCCTGTCAGCTGCCCTCCTCCACCTAAACCCCTTCGACTCTTCTGCTTTGACAAAGAAAAT GACATTGGGGAGGGGAGGTGCTCCGCCTCCCAGCTTTTCTCAAAATAGTCCTATAGATACTGGTAATCT GGAAATGAAGAAGTAATTCTGTCTCTGCACCTACTTTTGCAGAATGTTCAAGGAAGTATTCTGTGTTAG TATTAATGCCAAAAAGTTGTTTTTAAAGGTTTTGTACTCAGCACATCATACAAACCACATTACTTCTGT CACTTCAGGGCATCGGGACTGGCTGGCGCCCTTGTTATGTGCTATTTTAATCAGTGTAACATTGGTCAA GTTGTTACCCATGTATGCTGTGTTTATCATGTGTATATCGTCCAGAAAGTATTAAGGCTTTAGGTAGAT GCAACTGGCGAACCTTGGAGAGGGAATGCTGATTGTCTTGACCAAACCCACAGCCTGTCTCTTCTCTTG TTTAGTTACTTACGGCAATAAATCATCTATGAGTTAGTGCACCGTGA ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_015150.2
Synonyms	MIG2; PIB10; PIG9; RAFTLIN
Summary	Involved in protein trafficking via association with clathrin and AP2 complex (PubMed:27022195, PubMed:21266579). Upon bacterial lipopolysaccharide stimulation, mediates internalization of TLR4 to endosomes in dendritic cells and macrophages; and internalization of poly(I:C) to TLR3-positive endosomes in myeloid dendritic cells and epithelial cells; resulting in activation of TICAM1-mediated signaling and subsequent IFNB1 production (PubMed:27022195, PubMed:21266579). Involved in T-cell antigen receptor-mediated signaling by regulating tyrosine kinase LCK localization, T-cell dependent antibody production and cytokine secretion (By similarity). May regulate B-cell antigen receptor-mediated signaling (PubMed:12805216). May play a pivotal role in the formation and/or maintenance of lipid rafts (PubMed:12805216).[UniProtKB/Swiss-Prot Function]
Locus ID	23180
MW	36.9

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