Topoisomerase II alpha (TOP2A) (NM_001067) Human 3' UTR Clone

Specifications

Product Data
Product Name	Topoisomerase II alpha (TOP2A) (NM_001067) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	TOP2; TOP2alpha; TOPIIA; TP2A
ACCN	NM_001067
Insert Size	1024 bp
Sequence Data	Insert Sequence (showhide) >SC211510 3’UTR clone of NM_001067 The sequence shown below is from the reference sequence of NM_001067. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC GAAGAGTCAGATGAAGATGATCTGTTTTAAAATGTGAGGCGATTATTTTAAGTAATTATCTTACCAAGC CCAAGACTGGTTTTAAAGTTACCTGAAGCTCTTAACTTCCTCCCCTCTGAATTTAGTTTGGGGAAGGTG TTTTTAGTACAAGACATCAAAGTGAAGTAAAGCCCAAGTGTTCTTTAGCTTTTTATAATACTGTCTAAA TAGTGACCATCTCATGGGCATTGTTTTCTTCTCTGCTTTGTCTGTGTTTTGAGTCTGCTTTCTTTTGTC TTTAAAACCTGATTTTTAAGTTCTTCTGAACTGTAGAAATAGCTATCTGATCACTTCAGCGTAAAGCAG TGTGTTTATTAACCATCCACTAAGCTAAAACTAGAGCAGTTTGATTTAAAAGTGTCACTCTTCCTCCTT TTCTACTTTCAGTAGATATGAGATAGAGCATAATTATCTGTTTTATCTTAGTTTTATACATAATTTACC ATCAGATAGAACTTTATGGTTCTAGTACAGATACTCTACTACACTCAGCCTCTTATGTGCCAAGTTTTT CTTTAAGCAATGAGAAATTGCTCATGTTCTTCATCTTCTCAAATCATCAGAGGCCGAAGAAAAACACTT TGGCTGTGTCTATAACTTGACACAGTCAATAGAATGAAGAAAATTAGAGTAGTTATGTGATTATTTCAG CTCTTGACCTGTCCCCTCTGGCTGCCTCTGAGTCTGAATCTCCCAAAGAGAGAAACCAATTTCTAAGAG GACTGGATTGCAGAAGACTCGGGGACAACATTTGATCCAAGATCTTAAATGTTATATTGATAACCATGC TCAGCAATGAGCTATTAGATTCATTTTGGGAAATCTCCATAATTTCAATTTGTAAACTTTGTTAAGACC TGTCTACATTGTTATATGTGTGTGACTTGAGTAATGTTATCAACGTTTTTGTAAATATTTACTATGTTT TTCTATTAGCTAAATTCCAACAATTTTGTACTTTAATAAAATGTTCTAAACATTGCAA ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_001067.4
Synonyms	TOP2; TOP2alpha; TOPIIA; TP2A
Summary	This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, alpha, is localized to chromosome 17 and the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia. [provided by RefSeq, Jul 2010]
Locus ID	7153
MW	39.7

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