UPF3A (NM_080687) Human 3' UTR Clone

Specifications

Product Data
Product Name	UPF3A (NM_080687) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	HUPF3A; RENT3A; UPF3
ACCN	NM_080687
Insert Size	930 bp
Sequence Data	Insert Sequence (showhide) >SC211038 3’UTR clone of NM_080687 The sequence shown below is from the reference sequence of NM_080687. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC GGTCCTGAGAAGAGGGAAGAGGCAGAGTGAGTCACTGCACGCACCTGGCCTCCATGGACGAGCAAGGGC ATCCCAGAAACGTGTAAATGACCCCGAGTGTGACTGGGAAGGAGAACTTATTCCTTACCAGGAAACTGG AAGCTAAAAATACAGAGGGTGACGTAGAAACACGCAGAAACCATTCTAAAGAAAGTAGTGATCTTGTAT TAAATTGAGCAGAATTCTCACAGATTTTACCATTCCTGTTATAAACTAGTATTTGTTGTTTAGCCAAAA CAGAAAATGATTTCCACTGGACAGTAGAAAAATATGTGTAAAATAGGGAAGAAAGTTAGTATTGGATCA GTGTGAGTCCTGAAGCACTTTCAGTGCTGTGAGAACGACATCCACTTTGGGTTTCATTCGTTTGTAAGC AGAGGAGCTGTCAGTCACTCGTGCTTCTCGGTGGCCTCTGAGCCATGGTGTCGAGTGAAGAGTAGTTCT TGTTTGTTACAACCTTTGTGAGTCAGCCATGCCCGCAAAGCGTGCTGTGTTTTAGTCCTGGTAGGAATA TTTATCAGAGTTCACACTATATAAAACCCAACAGCTTCAACTATTGCCCTTTCAACAGTTTTGCCACTG ACCGGATAGAAACGGTTTCAGTCTCTGGATGGATGTGTTTGTGGTTTGTAACCATTACGGTTTAAACCA TGGTTTAAGAATTTGCCCAAATAACAGAAATTTTGTTCGGGAAGGGATAAACTAGATATAGCATACAGA GCCTGTTTTTGAGTTTTAGATACTTTATTTGTAAATAACTTAAAATAGCTTTCTGAAACCGTGCATTCT GTAGTTTCTTCCTTTCAGTGAAATTGCTAAATGTCAATGTATTTTTGGCACTGCGATTTTAACCATTTA TTAAATAAAAATTTTGTTAAAGAAGTACTGAAA ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_080687.3
Synonyms	HUPF3A; RENT3A; UPF3
Summary	This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. The encoded protein is one of two functional homologs to yeast Upf3p. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein binds to the mRNA and remains bound after nuclear export, acting as a nucleocytoplasmic shuttling protein. It forms with Y14 a complex that binds specifically 20 nt upstream of exon-exon junctions. This gene is located on the long arm of chromosome 13. Several splice variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2017]
Locus ID	65110
MW	35.4

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