MRI (C7orf49) (NM_024033) Human 3' UTR Clone

Specifications

Product Data
Product Name	MRI (C7orf49) (NM_024033) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	C7orf49; MRI; MRI-2
ACCN	NM_024033
Insert Size	856 bp
Sequence Data	Insert Sequence (showhide) >SC210426 3’UTR clone of NM_024033 The sequence shown below is from the reference sequence of NM_024033. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC AAATACGTCCGGGAGATCTTTTTCAGCTAGGGCATAAACTGTGCACTGAACTGTCTGCCGAGAGCAGCT GGAGGACAGCTGAGCTTCCACTGGTGCTGCTGGGCCGCCCGCCTGTGGGAATGGGGCTCTCTGTGCTCC TACCTTTGTGCCTTCTTGGGCCTGGCAGATTCACCTCAGGCCAGAAGCCCCTGGACACTCCGGGCCTTG GGGCTGCCGTTCTGAGTGTGCGGAAGGCAGGACTCAAAATGAGATCCCATTTGACTCCCTCTGTATGTA CTGTGCCCTCTCCTGGCTCTTGAGGCTCTGGAGTCCCAATTGTCTGTGTTAGTCAGTGACCAGGTTCCA GGGAAAATGATGTCATGTGGTGGTCCAACTTACTGGAACCAAAGAGACAGTACTTTGCAAAGAAAAGGA TCACTGCCAGGTGCACTGGAATTGCTACAGTTTAGTCCGCATGATCTCTCCTGAAGGAGGAAGCCTGTT TCAAAAATAGTTTCCATCATGAGTCTATCAATGAGCTCCCACCTCTCCAGCCAGCCTAGAAAGCAAACG AGCTGCCCACAGTTCTCTGCCCTGTCTGGGAGGTTGAGGCCACAGTGTATAGACTGGTAAGCCAGACAG GCCTCCTCCCGCAAGCTGCTACCTTGCTTTCACCTGTACCTTGGTCCCCGGGCAGCTAGCTATAAAGCA AGAGGGACAGGAGCCCAGAAGAGACACTGAGGACAAGAGATCACACCAGAGTACATGTCTCTGCCTCTG TTTTCAGTGTGGCTTTGGACAGGAATATATGAATAAATCACTGCCATACAGGTTTTCCAATACACAAGT GCTAGAAAATACACACAATTCCCCAATG ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_024033.4
Synonyms	C7orf49; MRI; MRI-2
Summary	Isoform 1: Cell-cycle-specific inhibitor of classical non-homologous end joining (NHEJ) of DNA double-strand break (DSB) repair during the S and G2 phases (PubMed:28959974). Acts as a regulator of DNA repair pathway choice by specifically inhibiting classical NHEJ during the S and G2 phases, thereby promoting error-free repair by homologous recombination during cell cycle phases when sister chromatids are present (PubMed:28959974). Preferentially protects single-stranded overhangs at break sites by inhibiting classical NHEJ, thereby creating a local environment that favors homologous recombination (PubMed:28959974). Acts via interaction with XRCC5/Ku80 and XRCC6/Ku70, interaction restricted during the S and G2 phases only (PubMed:28959974). Molecular mechanisms governing classical NHEJ inhibition via interaction with XRCC5/Ku80 and XRCC6/Ku70 are unknown (PubMed:28959974). May act as a regulator of proteasome (By similarity).[UniProtKB/Swiss-Prot Function]
Locus ID	78996
MW	32

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