RBM16 (SCAF8) (NM_014892) Human 3' UTR Clone

Specifications

Product Data
Product Name	RBM16 (SCAF8) (NM_014892) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	RBM16
ACCN	NM_014892
Insert Size	856 bp
Sequence Data	Insert Sequence (showhide) >SC208833 3’UTR clone of NM_014892 The sequence shown below is from the reference sequence of NM_014892. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC GTAGAAAGCACAGAAACTGAGGGGACATAATCATCACTCAGTAGGTAAAAGATACCTTTTGTAAAGTTG TCATCTCTCTGTAATAGATAATGGCTGACTGGACCATAGTTGTTCACTTTTGTCTGCCAGAATTAAGTT AATCTGATGTTCATGTTCACCTTTCTCTTAAAATAATTGTACAACTGACTTGTATAGACATTGTTCTTA ATATGAACATGGTAGGTAAACTTTTTTTTTATTTTTTTCTGATAAAATACAAATGTTGGCCCCAGATTC TTTTAACGTCAAGGAAATGAATAACAGCTTGTCAGAGACTTCCTATGGAAGAAAGAATTTTTTAGATAC TATCATTAGGTTGGATATGGTAATAGATATATTTCAGAATAGCAAGTGGTGGTATATCTTATCCATATC TTTAGGCTGCTGCAGAATTTTAAGGTTATAGATAAAGCTGTGATATTTTATGCAAAGACTGGCTCTAGG TATTTGAGGAGCACAATACAGAGATTTTAAAAAGTGATTTTGTAAAATCTACACTACGGTCTCTGTTTC TCCAAAGTAAGTGTTTGTGATTTGTTCCTCATACTGCAGTGAGTAAAAAAGAAACAAGAAAACAACAAC ATAAATATTAAAGTACGTTTCAATGTTGGGTGAATTTTGTTTTTAGATGCCAATAAAACTTATTTGTTT GATAACAGTGTTCTAGGAATTGTATTTTTTTAACCTATAAATTCTTAAAACCTTGAATTATTATTAGCA TGTGCTTATTTTTTGCAAAAGCTTTCTATCATAACAACAATGAACTATGTGGTGGAAAAAGCATGTACT TTGATATAAAAATCATGCAGCCTCCTCA ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_014892.5
Synonyms	RBM16
Summary	Anti-terminator protein required to prevent early mRNA termination during transcription (PubMed:31104839). Together with SCAF4, acts by suppressing the use of early, alternative poly(A) sites, thereby preventing the accumulation of non-functional truncated proteins (PubMed:31104839). Mechanistically, associates with the phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit (POLR2A), and subsequently binds nascent RNA upstream of early polyadenylation sites to prevent premature mRNA transcript cleavage and polyadenylation (PubMed:31104839). Independently of SCAF4, also acts as a positive regulator of transcript elongation (PubMed:31104839).[UniProtKB/Swiss-Prot Function]
Locus ID	22828
MW	33.5

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