JAML (NM_153206) Human 3' UTR Clone

Specifications

Product Data
Product Name	JAML (NM_153206) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	AMICA; AMICA1; CREA7-1; CREA7-4; Gm638
ACCN	NM_153206
Insert Size	630 bp
Sequence Data	Insert Sequence (showhide) >SC207915 3’UTR clone of NM_153206 The sequence shown below is from the reference sequence of NM_153206. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC GGAATGCCAAAAACACAGCAAGCCTTTTGAGAAGAATGGAGAGTCCCTTCATCTCAGCAGCGGTGGAGA CTCTCTCCTGTGTGTGTCCTGGGCCACTCTACCAGTGATTTCAGACTCCCGCTCTCCCAGCTGTCCTCC TGTCTCATTGTTTGGTCAATACACTGAAGATGGAGAATTTGGAGCCTGGCAGAGAGACTGGACAGCTCT GGAGGAACAGGCCTGCTGAGGGGAGGGGAGCATGGACTTGGCCTCTGGAGTGGGACACTGGCCCTGGGA ACCAGGCTGAGCTGAGTGGCCTCAAACCCCCCGTTGGATCAGACCCTCCTGTGGGCAGGGTTCTTAGTG GATGAGTTACTGGGAAGAATCAGAGATAAAAACCAACCCAAATCATTCCTCTGGCACATTATTTCTAAA TAAGTGTTGTTTGTGGAAATCGTCCTATTTTTATGCCTCGGTTGAGGGGGCAAGTAAAGTCCTGGTGAG GAATTTACAGTTAGAAACTTTTGGAAAAACTGAAGTTCCTGGAGGAAAGCCAAACCGTGCTAACACACT AGAGGCTGGTTTTGGTCCTGGGAAAGGTTTGGGGTGAATGGGTTGGAAGTAGGGTATGAATACAGTTTT GGGATTTAA ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_153206.3
Synonyms	AMICA; AMICA1; CREA7-1; CREA7-4; Gm638
Summary	Transmembrane protein of the plasma membrane of leukocytes that control their migration and activation through interaction with CXADR, a plasma membrane receptor found on adjacent epithelial and endothelial cells. The interaction between both receptors mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair. It also controls the transmigration of leukocytes within epithelial and endothelial tissues through adhesive interactions with epithelial and endothelial CXADR.[UniProtKB/Swiss-Prot Function]
Locus ID	120425
MW	23.8

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