C3orf37 (HMCES) (NM_020187) Human 3' UTR Clone

Specifications

Product Data
Product Name	C3orf37 (HMCES) (NM_020187) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	C3orf37; DC12; SRAPD1
ACCN	NM_020187
Insert Size	1391 bp
Sequence Data	Insert Sequence (showhide) >SC206558 3’UTR clone of NM_020187 The sequence shown below is from the reference sequence of NM_020187. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC CCTGTGGCCAAGCGTCCTTACAGCCAGTGACACAGGACTTTCAGAGACCAAGGCCAGGGTCTGCTGCAC TGCTGTTCTGATAATAGGTTCTTAACATTGTATGTATATGTGTTTGCTTTGGGAGGAGGTGGCACTGTG TTAGTTGACAGTTGTGGGCTCATGTAGTCTTTTTTGCCATGAGTAGGAGCCCCTAGTGGGGCTGGTGGA CAGCTTTGGAAGAGGTGTCCTGCTGCTGTTACCAGCCATGTGGGCCCCATAGGGGCACTGCGCCTGCTG CCCTTTCCTGGCAGGGCTGGTGGAGTCTTCCCTCAAAGCATGCCTTACCCAGCTGGGAAGTCTCTGCCC TGATCTGGTACTCCTTGTAGTAAGCTGTTTTCTGCTCAGCCACTGGGCTCTTTCACTTTTTTAGTTCTT AAAAATTTATTTTTAAGTTCTAAAATAAAATAAAAATAAGTTCTTAAAATTTATTTTTTTCCTGAATAA ATTGTATTTGGTAAACTTCTGCCTACATTTTGGAAAGTGATGCTGGTGGGGAAAGTTCTAGATCTTACT TGGTTTCTTCTAGAATCAGTCTTCAGGAATGGATTTTGTCACAAATGGGGCATGGGGGCTTTCTGAGGA AATAACTACAAGTCTTGGTGGTGGGCTCCTTATTATGTTTCTTTTTCTTTCATTCTTGATACTTGGAAG TCGTCTGAATCCTTTAGCTTCAAACCAGCCTGAGTTTGAGTGCTTGCCGTAGCAGAAACTATCCTTACC ACAGGTGGGAAGGAAAGGACCAGTTTCTAGCAGTGTCGGGCCACTCCTCTTTCGAACATCCCTAAGGGA GGCATTCACAAAAGCTGTCCCAAGCAGCTGGAAGAAAACAGCTTCCGAGATGACCAGGAGGACTGGGCG GCGCCGAGCCCAGAACGCTCCTGGCGCAGCACCGTTGGCGTTGGCCGATTGCTGCTGGTGGGGGGCGGG GGTGCAGGCCCCAGTCTCTATGCAAATCAGGGATCAGAAGATCGGAATTTCCACCAATCAGCGGGAAGC CTCGGCCCTGTAACTGCTAATGGGAGACAGCAGCGCCACGCCACAGGCTTTTCCCCTGGTTTCGGGAGG GGTGGGGAGCCAGGTGGGGCTCCCGCCCAGACCCTTTCCCGAGGTCCGCCCTCTCCGCCTTTTCTCTAA ATTCCTCTTTTGAGTGCCCTCCCTTCCGGTTGAGAGGCGGGGGTTGGCCCGTAGTTGTACACTCAGTCA CCCTGCACTGTGGAGGCGGGGGCCTCCCTTGTGGACTGATTTGCGTGGGATTTGGTTGTTTTATTAAGA GATTTAAAAAATTCAGATGACTTACTAGTATGACTGTTTTGTCATATTTGCTTCCAGGTTAATAAATGA CAAAAATGAAA ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_020187.3
Synonyms	C3orf37; DC12; SRAPD1
Summary	Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites (PubMed:30554877). Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA (PubMed:30554877). The HMCES DNA-protein cross-link is then degraded by the proteasome (PubMed:30554877). Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endonucleases that are error-prone and would generate mutations and double-strand breaks (PubMed:30554877). Acts as a protease: mediates autocatalytic processing of its N-terminal methionine in order to expose the catalytic cysteine (By similarity). Specifically binds 5-hydroxymethylcytosine (5hmC)-containing DNA in stem cells (By similarity). May act as an endonuclease that specifically cleaves 5hmC-containing DNA; additional experiments are however required to confirm this activity in vivo (By similarity).[UniProtKB/Swiss-Prot Function]
Locus ID	56941
MW	50.1

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