p8 (NUPR1) (NM_001042483) Human 3' UTR Clone

Specifications

Product Data
Product Name	p8 (NUPR1) (NM_001042483) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	COM1; P8
ACCN	NM_001042483
Insert Size	2000 bp
Sequence Data	Insert Sequence (showhide) >SC204951 3’UTR clone of NM_001042483 The sequence shown below is from the reference sequence of NM_001042483. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC GAGAGGAAGAAGCGAGGGGCACGGCGCTGAGACAGAGCTGGAGATGAGGCCAGACCATGGACACTACAC CCAGCAATAGAGACGGGACTGCGGAGGAAGGAGGACCCAGGACAGGATCCAGGCCGGCTTGCCACACCC CCCACCCCTAGGACTTATTCCCGCTGACTGAGTCTCTGAGGGGCTACCAGGAAAGCGCCTCCAACCCTA GCAAAAGTGCAAGATGGGGAGTGAGAGGCTGGGAATGGAGGGGCAGAGCCAGGAAGATCCCCCAGAAAA GAAAGCTACAGAAGAAACTGGGGCTCCTCCAGGGTGGCAGCAACAATAAATAGACACGCACGGCAGCCA CAGCTTGGGTGTGTGTTCATCCTTGTTCTTTGTGTGTTTTTGTTCGGGCATGTGTGTGCTTGCCTGTGC CTGCACATTCATGAGCCTGAGAGAGCATCTTTGATGTGTATTTGTGTTTGGTGTATGTATCTGGGGCAG GGAGTGTTCCTGCTCTTGCAGGGTCTACGCTGTGAATGCAGCTTTTGGTTTGTTTGCTTTTGCTTGCAT ATATTTTAGTGCATACATTTCTGTGGGCTCCTACGTAGTGGAAAGGAATTTCTTCTGCTTTTTTGCGAT ACTGCCCATGAAACACGGCCCTCCCCAGCACCTGTTTTTGTTGATTGTGTCCTGTTCATAGACGGGAAC GCTACTTATGAGTGCCATCTAAAAGTCAGAGAAAACTGAGATTTAAAATATTAAAAGCCAGGGCCGGGG GCAGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGTGGGTGGATCACAAAGTCAGGAGTT CAAGACCAGCCTGACCAACATGGTGAAACCCCATCTCCACTAAAAATACCAAAAATTAGCCAAGCATGG TGGCAGGTGCCTGTAATCCCAGCTGCTCAGGAGGCTGAGGCAGTAGAATCGCTTGAACCCAGGAGGTAG AGGTTGCAGTGAGCCGACATCGTGCCATTGCACTCCAGCCTGGGTGACAGAGGGAGACTCTGTCTCAAA ACAAACAAACAAACAAAAACTAAAGTCTGGGAGCAGTGGCTCATGCCTGTAATCACAGCAGTTTAGGAG GCCGAAGTGGGAGGATTACTTGAGCCTAGGAGTTTGAGACCAGCCTGAGCATCATAGTAAGACCCCATC TCTACAATTTTTTTTTTGAGACAGAGTCTCACTCTGTTGCTCAGGTTAGAGTGCAGTGGCACCATCTTG GCTCACTGCAACCTCTGCCTCCCGGGTTCAAGCAATTCTCGTGCCTACGCCCCCTGAGTAGCTGGGATT ACAGGTGAGCACCACCACGCCTGGCTAATTTTTGTTTTTTTGTTTTTTTGATACAGAGTCTCACTCTGT TGCTCAGGCTGGAGTGCAGTGGCATGATCGCAGCTCACTGCAACCTCCGCCTCCTGGGTTCAAGCTATT CTCCTGCTTCAGCCTCCTGAGTAGCTGGGACTACAGGCACCTGCCACCATGCCTGGCTAATTTTTGTAT TTTTAGTAGAAACAGAGTTTCACCATGTTGGCCAGGATGGTCTCAATCTCTTGACCTCATGATCCACCC ACCTTGGCCTCCCAAAGTGCTGGGATTACAGGCGTCAGCCACCACGCCTGGCCAATTTTTGTATTTTTA GTAGAGATGGGGTTTCATCATGTTGGCCAGGCTGGTCTCAAACTCCTGGCCTCAAATGATCTGCCCACC TCAGCCTTCCAGCCTTTGGGAGGCCAAGGAGGGAGGATCGCTTGAGGCCAGGAGTTCGAGACCAGCCTA GGCAACATACCAAGGCCCTGTCTCTACAAAAATTTAAAAATTAGCAAAGCATGGTGGCTCATGCCTGTA GTCCTAGTTGCTCAGAGGCTGAAGTTGGAGGATCCCTTGAACCCAGTTGGAGGCTACAGTAAGCCATGA TGGTGCCACTGCACTGCAGCCTGAGCAATAGAGTGAAACCATGTATTGAAAAAGAAAGAAAGAAAGAA ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_001042483.2
Synonyms	COM1; P8
Summary	Transcription regulator that converts stress signals into a program of gene expression that empowers cells with resistance to the stress induced by a change in their microenvironment. Thereby participates in regulation of many process namely cell-cycle, apoptosis, autophagy and DNA repair responses (PubMed:16478804, PubMed:19650074, PubMed:16300740, PubMed:19723804, PubMed:11056169, PubMed:22858377, PubMed:11940591, PubMed:18690848, PubMed:22565310, PubMed:20181828, PubMed:30451898). Controls cell cycle progression and protects cells from genotoxic stress induced by doxorubicin through the complex formation with TP53 and EP300 that binds CDKN1A promoter leading to transcriptional induction of CDKN1A (PubMed:18690848). Protects pancreatic cancer cells from stress-induced cell death by binding the RELB promoter and activating its transcription, leading to IER3 transactivation (PubMed:22565310). Negatively regulates apoptosis through interaction with PTMA (PubMed:16478804). Inhibits autophagy-induced apoptosis in cardiac cells through FOXO3 interaction, inducing cytoplasmic translocation of FOXO3 thereby preventing the FOXO3 association with the pro-autophagic BNIP3 promoter (PubMed:20181828). Inhibits cell growth and facilitates programmed cell death by apoptosis after adriamycin-induced DNA damage through transactivation of TP53 (By similarity). Regulates methamphetamine-induced apoptosis and autophagy through DDIT3-mediated endoplasmic reticulum stress pathway (By similarity). Participates to DNA repair following gamma-irradiation by facilitating DNA access of the transcription machinery through interaction with MSL1 leading to inhibition of histone H4' Lys-16' acetylation (H4K16ac) (PubMed:19650074). Coactivator of PAX2 transcription factor activity, both by recruiting EP300 to increase PAX2 transcription factor activity and by binding PAXIP1 to suppress PAXIP1-induced inhibition on PAX2 (PubMed:11940591). Positively regulates cell cycle progression through interaction with COPS5 inducing cytoplasmic translocation of CDKN1B leading to the CDKN1B degradation (PubMed:16300740). Coordinates, through its interaction with EP300, the assiociation of MYOD1, EP300 and DDX5 to the MYOG promoter, leading to inhibition of cell-cycle progression and myogenic differentiation promotion (PubMed:19723804). Negatively regulates beta cell proliferation via inhibition of cell-cycle regulatory genes expression through the suppression of their promoter activities (By similarity). Also required for LHB expression and ovarian maturation (By similarity). Exacerbates CNS inflammation and demyelination upon cuprizone treatment (By similarity).[UniProtKB/Swiss-Prot Function]
Locus ID	26471
MW	73.6

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