MRP2 (ABCC2) (NM_000392) Human 3' UTR Clone

Specifications

Product Data
Product Name	MRP2 (ABCC2) (NM_000392) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	ABC30; CMOAT; cMRP; DJS; MRP2
ACCN	NM_000392
Insert Size	993 bp
Sequence Data	Insert Sequence (showhide) >SC203492 3’UTR clone of NM_000392 The sequence shown below is from the reference sequence of NM_000392. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC ATTGAGAATGTGAACAGCACAAAATTCTAGCAGAAGGCCCCATGGGTTAGAAAAGGACTATAAGAATAA TTTCTTATTTAATTTTATTTTTTATAAAATACAGAATACATACAAAAGTGTGTATAAAATGTACGTTTT AAAAAAGGATAAGTGAACACCCATGAACCTACTACCCAGGTTAAGAAAATAAATGTCACCAGGTACTTG AGAAACCCCTCGATTGTCTACCTCGATCGTACTTCCTTGCTACCCACCCCTCCCAGGGACAACCACTGT CCTGAATTTCACGATAATTATTCCTTTGCCTTTCATTTCTGTTTTATCACCTTTGTATGTATCTTTAAA CAACATATACCCTTTTTTACTTATGTAAATGGACTGACTCATACTGCATACATCTTCTATGACTTGATT CTTTTGTTCAATATTATATCTGAGATTCATCCATGGTGATGCAAATAGGTGCATTATTTTTTTTCACTG CTCTGTAGTCTGGCATTGTATGAATACAGCACAATGTATCAGTTTTAATATTGGGGATCATTAGCATTA TTCTCAGGTTTTTAAAAATTATAAGCAGTACTACTATGGACATTCTGGTCTACATCTCCTGGCACATAT GTAAGAGTTTCTCTAGGGTATAACCTAGGAATGGAGGGTATGAACATGTTTACATGCACAAACTAGCTG ATGCCAAACTGGTAATGCCAACTGAAAACATTGCTGTCAATCTGATGAATATGAATTGATGTATCAATG AGAATTTCATTTGCATTTCCCTAGTATCTATTGGGGATGAATATATTTTCATGTTTCTGGGGCATTTGC ATTTCCACTTGTTTTTTAAATATTGTGTCTGATAATTCCAATGTCTGGATTCTTTGTTTATCTGTTGTT TCTGTTGGTTTTTACTCATGGTATTTTATTTCCTTGTATGTCTTGTGAATTTTTATTATAAGCTCGTTC TCCTTAAAACTTTATCTGTGGACATTC ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_000392.5
Synonyms	ABC30; CMOAT; cMRP; DJS; MRP2
Summary	The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is expressed in the canalicular (apical) part of the hepatocyte and functions in biliary transport. Substrates include anticancer drugs such as vinblastine; therefore, this protein appears to contribute to drug resistance in mammalian cells. Several different mutations in this gene have been observed in patients with Dubin-Johnson syndrome (DJS), an autosomal recessive disorder characterized by conjugated hyperbilirubinemia. [provided by RefSeq, Jul 2008]
Locus ID	1244
MW	39

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