CLACP (COL25A1) (NM_032518) Human 3' UTR Clone

Specifications

Product Data
Product Name	CLACP (COL25A1) (NM_032518) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	AMY; CFEOM5; CLAC; CLAC-P; CLACP
ACCN	NM_032518
Insert Size	276 bp
Sequence Data	Insert Sequence (showhide) >SC202593 3’UTR clone of NM_032518 The sequence shown below is from the reference sequence of NM_032518. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC TTGCTGTTCAGCTTGTGTGATTCCATTTGACACTTAATCTTTCTCCATCCTGTGCTCCAAAAACATACT GATGCCTGATTTAAGGAATCAGGTCTTCAGAGAGGAATGAAGAAGGCTGTACTGCCAGATATAAGGGCA CTGCCTGGCATAGAAGAAAAAATTATTATCACCAGATATTCTAGCTACAGTTTTTCAACCACCTGACAC CAATTTATGGAAAAATAAAGGATTTTTGAAAAAAAAATCATTTTAAAAAGTAAAATTAAATGACACAAA ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_032518.4
Synonyms	AMY; CFEOM5; CLAC; CLAC-P; CLACP
Summary	This gene encodes a brain-specific membrane associated collagen. A product of proteolytic processing of the encoded protein, CLAC (collagenous Alzheimer amyloid plaque component), binds to amyloid beta-peptides found in Alzheimer amyloid plaques but CLAC inhibits rather than facilitates amyloid fibril elongation (PMID: 16300410). A study of over-expression of this collagen in mice, however, found changes in pathology and behavior suggesting that the encoded protein may promote amyloid plaque formation (PMID: 19548013). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
Locus ID	84570
MW	10.8

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