Separase (ESPL1) (NM_012291) Human 3' UTR Clone

Specifications

Product Data
Product Name	Separase (ESPL1) (NM_012291) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	ESP1; SEPA
ACCN	NM_012291
Insert Size	194 bp
Sequence Data	Insert Sequence (showhide) >SC202001 3’UTR clone of NM_012291 The sequence shown below is from the reference sequence of NM_012291. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC GCCTATGGCTTGCCTGTCTCTCTGCGGTAACCCCATGGAGCTGTCTTATTGATGCTAGAAGCCTCATAA CTGTTCTACCTCCAAGGTTAGATTTAATCCTTAGGATAACTCTTTTAAAGTGATTTTCCCCAGTGTTTT ATATGAAACATTTCCTTTTGATTTAACCTCAGTATAATAAAGATACATCATTTAAA ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_012291.5
Synonyms	ESP1; SEPA
Summary	Stable cohesion between sister chromatids before anaphase and their timely separation during anaphase are critical for chromosome inheritance. In vertebrates, sister chromatid cohesion is released in 2 steps via distinct mechanisms. The first step involves phosphorylation of STAG1 (MIM 604358) or STAG2 (MIM 300826) in the cohesin complex. The second step involves cleavage of the cohesin subunit SCC1 (RAD21; MIM 606462) by ESPL1, or separase, which initiates the final separation of sister chromatids (Sun et al., 2009 [PubMed 19345191]).[supplied by OMIM, Nov 2010]
Locus ID	9700
MW	7.2

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