SHARPIN (NM_030974) Human 3' UTR Clone

Specifications

Product Data
Product Name	SHARPIN (NM_030974) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	SIPL1
ACCN	NM_030974
Insert Size	194 bp
Sequence Data	Insert Sequence (showhide) >SC201700 3’UTR clone of NM_030974 The sequence shown below is from the reference sequence of NM_030974. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC TGGGACCCCCTTGCTGCAGCTTCCACCTAGCAGCCACCAGAGGTTACAAGGGGAGAGTGGCCCTTCCCT CACAAGTCCGACATCTCCAGGCCCCCACTGAACTCCGGGGACCTCTACTGACTGCTTGCTGGGACAGTC ACCAGGGTTGGGGGGAAGGGCCACAAAATGAAACCATTAAAGACCCTTAAGAGCCA ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_030974.4
Synonyms	SIPL1
Summary	Component of the LUBAC complex which conjugates linear polyubiquitin chains in a head-to-tail manner to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways. Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation. LUBAC is recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex. Together with OTULIN, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis.[UniProtKB/Swiss-Prot Function]
Locus ID	81858
MW	7

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