MICAL3 (NM_001122731) Human 3' UTR Clone

Specifications

Product Data
Product Name	MICAL3 (NM_001122731) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	MICAL-3
ACCN	NM_001122731
Insert Size	160 bp
Sequence Data	Insert Sequence (showhide) >SC201058 3’UTR clone of NM_001122731 The sequence shown below is from the reference sequence of NM_001122731. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC CCTCCCACAGTGCTGGGATCACAGATGTGAGCTACTGGGCCCAGCTGAGCATAAGAGTCTTTTCTGTGT CACCTTTGTGTTCCCTACAGTGTCTAGCAAGTGCGTTGTGAGGGGAAGATAATTGAATAAATTTTATCC AGGTAAAAAAAAAAAAAAAAAA ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_001122731.2
Synonyms	MICAL-3
Summary	Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization. In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2). Seems to act as Rab effector protein and plays a role in vesicle trafficking. Involved in exocytic vesicles tethering and fusion: the monooxygenase activity is required for this process and implicates RAB8A associated with exocytotic vesicles. Required for cytokinesis. Contributes to stabilization and/or maturation of the intercellular bridge independently of its monooxygenase activity. Promotes recruitment of Rab8 and ERC1 to the intercellular bridge, and together these proteins are proposed to function in timely abscission.[UniProtKB/Swiss-Prot Function]
Locus ID	57553
MW	5.9

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