ALKBH7 (NM_032306) Human 3' UTR Clone

Specifications

Product Data
Product Name	ALKBH7 (NM_032306) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	ABH7; SPATA11; UNQ6002
ACCN	NM_032306
Insert Size	307 bp
Sequence Data	Insert Sequence (showhide) >SC200061 3’UTR clone of NM_032306 The sequence shown below is from the reference sequence of NM_032306. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC GAGTCTGGACAGCCGCCCCCAGCCTGCTGACCCCCAGCTTTCTACAGACACCAGATTTGTGAATAAAGT TGGGGAATGGACAGCCTAACTGGGACATTGCAGTGGCTGCTTGCTGGGGCCGGGATTTGCAGGGGAACC CAGGATGGCACTGGCCCATAGGGAGCTCCAGGTGTGGCTGGCTGGACACATGGTCAAAGTCACAAGGCC GGGAGAGTGGTGTCCTTTATTGCACTCACTGCTGGTCGCCCCAGCCCACTCCCCTCCTCGTTGTCTCTG CATCCAGGTCTCCAATAAATAAGTCAGCCGA ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_032306.4
Synonyms	ABH7; SPATA11; UNQ6002
Summary	May function as protein hydroxylase; can catalyze auto-hydroxylation at Leu-110 (in vitro), but this activity may be due to the absence of the true substrate (PubMed:25122757). Required to induce programmed necrosis in response to DNA damage caused by cytotoxic alkylating agents. Acts by triggering the collapse of mitochondrial membrane potential and loss of mitochondrial function that leads to energy depletion and cell death (PubMed:23666923). ALKBH7-mediated necrosis is probably required to prevent the accumulation of cells with DNA damage (PubMed:23666923). Does not display DNA demethylase activity (PubMed:23666923). Involved in fatty acid metabolism (By similarity).[UniProtKB/Swiss-Prot Function]
Locus ID	84266
MW	10.5

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.