Human CXCL11 ELISA KIT (96 T)

Specifications

Product Data
Description	Human CXCL11/ I-TAC Immunoassay
Size	96 T
Format	96-well strip plate
Assay Type	Solid Phase Sandwich ELISA
Assay Length	4 hours
Signal	Colorimetric
Curve Range	7.8-500 pg/ml
Sample Type	Serum, plasma, Cell culture supernatant
Sample Volume	100 uL
Specificity	This assay recognizes both natural and recombinant human CXCL11/I-TAC.
Sensitivity	4 pg/mL
Reactivity	Human
Interference	No significant interference observed with available related molecules.
Components	Microwell Plate - antibody coated 96-well Microplate (8 wells ×12 strips),1 plate Standard - lyophilized,1000 pg/ml upon reconstitution,2 vials Concentrated Biotin-Conjugated antibody(100X) - 120 ul/vial,1 vials Concentrated Streptavidin-HRP solution(100X) - 120 ul/vial,1 vial Standard /Sample Diluent - 16 ml/vial,1 bottle Biotin-Conjugate antibody Diluent - 16 ml/vial,1 bottle Streptavidin-HRP Diluent - 16 ml/vial,1 bottle Wash Buffer Concentrate (20x) - 30 ml/vial,1 bottle Substrate Solution - 12 ml/vial,1 bottle Stop Solution - 12 ml/vial,1 bottle Plate Cover Seals,4 pieces
Background	Interferon-inducible T cell Alpha Chemoattractant (I-TAC; also known as CXCL11) is a non-ELR (lacking the Glu-Leu-Arg tripeptide motif) CXC chemokine. The cDNA encoding I-TAC, originally designated β-R1, has also been reported as SCYB9B, H174 (4), IP-9, and SCYB11. I-TAC expression is significantly increased in response to IFN-β or IFN-γ, and is presumed to be involved in pathologies characterized by the presence of activated T cells. The I-TAC gene consists of four exons interrupted by three introns of 585, 98, and 230 base pairs. I-TAC cDNA encodes a 94 amino acid (aa) residue precursor protein with a 21 aa residue putative signal sequence that is cleaved to generate the mature protein. I-TAC is 36% and 37% identical in primary structure to the other non-ELR CXC chemokines IP-10 and MIG, respectively. Mouse I-TAC exhibits 68% aa sequence homology with human I-TAC. In humans, I-TAC, IP-10 and MIG all map to the same locus on chromosome 4.
Gene Symbol	CXCL11
Locus ID	6373

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