Human IL28A (IFNL2) ELISA KIT (96 T)

Specifications

Product Data
Description	Human IL-28A Immunoassay
Size	96 T
Format	96-well strip plate
Assay Type	Solid Phase Sandwich ELISA
Assay Length	4 hours
Signal	Colorimetric
Curve Range	125-8000 pg/ml
Sample Type	Serum, plasma, Cell culture supernatant
Sample Volume	100 uL
Specificity	This assay recognizes both natural and recombinant human IL-28A
Sensitivity	60 pg/mL
Reactivity	Human
Interference	No significant interference observed with available related molecules.
Components	Microwell Plate - antibody coated 96-well Microplate (8 wells ×12 strips),1 plate Standard - lyophilized,8000 pg/ml upon reconstitution,2 vials Concentrated Biotin-Conjugated antibody(100X) - 120 ul/vial,1 vials Concentrated Streptavidin-HRP solution(100X) - 120 ul/vial,1 vial Standard /Sample Diluent - 16 ml/vial,1 bottle Biotin-Conjugate antibody Diluent - 16 ml/vial,1 bottle Streptavidin-HRP Diluent - 16 ml/vial,1 bottle Wash Buffer Concentrate (20x) - 30 ml/vial,1 bottle Substrate Solution - 12 ml/vial,1 bottle Stop Solution - 12 ml/vial,1 bottle Plate Cover Seals,4 pieces
Background	IL-28A, also known as interferon λ 2, is a distant relative of IL-10 family and type I IFN family. IL-28A gene is located on chromosome 19 and each gene is composed of several exons. The exon tissue of these genes is also found in the IL-10 family, but unlike interferon I, it encodes only one exon. IL-28A exerts biological activity through viral infection or double strand RNA induced expression of. IL-28A cytokine overlapping type I interferon, including antiviral activity and MHC class I antigen expression. IL-28A protein emits signals through the same heterogeneous dimer receptor complex. These receptor complexes are composed of IL-10 receptor β and a novel IL-28 receptor α. Human IL-28A cDNA encodes a 200-amino acid (aa) precursor protein and a generally recognized 25-amino acid signal peptide. It shares 94% and 67% amino acid homology with human IL-28B and IL-29, respectively. Human/mouse IL-28A (IFN-lambda 2), IL-28B (IFN-lambda 3), and human IL-29 (IFN-lambda 1) are class II cytokine receptor ligands that are distantly related to members of the IL-10 family (11 - 13% amino acid (aa) sequence identity) and type I IFN family (15 - 19% aa sequence identity). These cytokines exert bioactivities that overlap those of type I IFNs, including antiviral activity and up-regulation of MHC class I antigen expression.
Gene Symbol	IFNL2

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