Human IL13 receptor alpha 2 (IL13RA2) ELISA KIT (96 T)

Specifications

Product Data
Description	Human IL-13Rα2 Immunoassay
Size	96 T
Format	96-well strip plate
Assay Type	Solid Phase Sandwich ELISA
Assay Length	4 hours
Signal	Colorimetric
Curve Range	156-10000 pg/ml
Sample Type	Serum, plasma, Cell culture supernatant
Sample Volume	100 uL
Specificity	This assay recognizes both natural and recombinant human IL-13Ra2
Sensitivity	80pg/mL.
Reactivity	Human
Interference	No significant interference observed with available related molecules.
Components	Microwell Plate - antibody coated 96-well Microplate (8 wells ×12 strips),1 plate Standard - lyophilized,10000 pg/ml upon reconstitution,2 vials Concentrated Biotin-Conjugated antibody(100X) - 120 ul/vial,1 vials Concentrated Streptavidin-HRP solution(100X) - 120 ul/vial,1 vial Standard /Sample Diluent - 16 ml/vial,1 bottle Biotin-Conjugate antibody Diluent - 16 ml/vial,1 bottle Streptavidin-HRP Diluent - 16 ml/vial,1 bottle Wash Buffer Concentrate (20x) - 30 ml/vial,1 bottle Substrate Solution - 12 ml/vial,1 bottle Stop Solution - 12 ml/vial,1 bottle Plate Cover Seals,4 pieces
Background	Interleukin 13 Receptor alpha 2 (IL 13 R alpha 2), also known as IL 13 binding protein, and CD213a2, is a widely expressed 55 kDa cytokine receptor that plays an important role in the Th2 polarized immune responses characteristic of a variety of pathologies, including parasitic infections and allergic asthma. Mature human IL 13 R alpha 2 consists of a 317 amino acid (aa) extracellular domain with three fibronectin type III domains, a WSxWS motif, a 20 aa transmembrane segment, and a 17 aa cytoplasmic domain. In both mouse and human, a 40 kDa 50 kDa soluble form of IL 13 R alpha 2 can be generated by MMP 8 mediated shedding in vitro. IL 13 R alpha 2 functions as a decoy receptor by binding and internalizing IL 13 and preventing it from signaling through the IL 13 R alpha 1/IL 4 R alpha complex. IL 13 R alpha 2 can also block IL 4 induced responses by inhibiting IL 4 bound IL 13 R alpha 1/IL 4 R alpha receptor complexes even though it does not itself bind IL 4.
Gene Symbol	IL13RA2
Locus ID	3598

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