bcl 6 (BCL6) Rabbit Monoclonal Antibody [Clone ID: UMAB299]

Specifications

Product Data
Clone Name	UMAB299
Applications	IHC
Recommend Dilution	IHC 1:1200
Reactivity	Human
Host	Rabbit
Clonality	Monoclonal
Immunogen	Synthetic peptide (the amino acid sequence is considered to be commercially sensitive) within Human BCL6 (NP_001697). The exact sequence is proprietary.
Isotype	IgG
Formulation	PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Concentration	1.00mg/ml
Purification	Purified from cell culture supernatant by affinity chromatography(protein A/G)
Conjugation	Unconjugated
Predicted Protein Size	78.7 kDa
Gene Name	BCL6 transcription repressor
Database Link	NP_001697 Entrez Gene 604 Human UniProt ID P41182
Background	The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of STAT-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Aug 2015]
Synonyms	BCL5; BCL6A; LAZ3; ZBTB27; ZNF51
Reference Data
Protein Families	Druggable Genome, Transcription Factors

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