MUM1 (IRF4) Mouse Monoclonal Antibody [Clone ID: UMAB280]

Specifications

Product Data
Clone Name	UMAB280
Applications	IHC
Recommend Dilution	IHC 1:250
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Full length human recombinant protein of human IRF4 (NP_002451) produced in HEK293T cell.
Isotype	IgG2a
Formulation	PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Concentration	1.00mg/ml
Purification	Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation	Unconjugated
Predicted Protein Size	51.8 kDa
Gene Name	interferon regulatory factor 4
Database Link	NP_002451 Entrez Gene 3662 Human UniProt ID Q15306
Background	The protein encoded by this gene belongs to the IRF (interferon regulatory factor) family of transcription factors, characterized by an unique tryptophan pentad repeat DNA-binding domain. The IRFs are important in the regulation of interferons in response to infection by virus, and in the regulation of interferon-inducible genes. This family member is lymphocyte specific and negatively regulates Toll-like-receptor (TLR) signaling that is central to the activation of innate and adaptive immune systems. A chromosomal translocation involving this gene and the IgH locus, t(6;14)(p25;q32), may be a cause of multiple myeloma. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2010].
Synonyms	LSIRF; MUM1; NF-EM5; SHEP8
Reference Data
Protein Families	Druggable Genome, Transcription Factors

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