XPF (ERCC4) Mouse Monoclonal Antibody [Clone ID: UMAB22]

Specifications

Product Data
Clone Name	UMAB22
Applications	10k-ChIP, IF, IHC
Recommend Dilution	WB 1:2000, IF 1:100, FLOW 1:100, IHC 1:500
Reactivity	Human, Mouse
Host	Mouse
Clonality	Monoclonal
Immunogen	Full length human recombinant protein of human XPF (NP_005227) produced in HEK293 cell.
Isotype	IgG2b
Formulation	Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)
Reconstitution Method	For reconstitution, we recommend adding 100uL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiment, we strongly recommend performing another round of desalting process. (OriGene recommends Zeba Spin Desalting Columns, 7KMWCO from Thermo Scientific)
Purification	Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	104.3 kDa
Gene Name	ERCC excision repair 4, endonuclease catalytic subunit
Database Link	NP_005227 Entrez Gene 50505 MouseEntrez Gene 2072 Human UniProt ID Q92889
Background	The protein encoded by this gene forms a complex with ERCC1 and is involved in the 5' incision made during nucleotide excision repair. This complex is a structure specific DNA repair endonuclease that interacts with EME1. Defects in this gene are a cause of xeroderma pigmentosum complementation group F (XP-F), or xeroderma pigmentosum VI (XP6).
Synonyms	ERCC11; FANCQ; RAD1; XFEPS; XPF
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Nucleotide excision repair

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