NEDD4 Mouse Monoclonal Antibody [Clone ID: OTI7A1]

Specifications

Product Data
Clone Name	OTI7A1
Applications	WB
Recommend Dilution	WB 1:500
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Human recombinant protein fragment corresponding to amino acids 160-460 of human NEDD4 (NP_940682) produced in E.coli.
Isotype	IgG2a
Formulation	PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Concentration	1 mg/ml
Purification	Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	140.7 kDa
Gene Name	neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
Database Link	NP_940682 Entrez Gene 4734 Human UniProt ID P46934
Background	This gene is the founding member of the NEDD4 family of HECT ubiquitin ligases that function in the ubiquitin proteasome system of protein degradation. The encoded protein contains an N-terminal calcium and phospholipid binding C2 domain followed by multiple tryptophan-rich WW domains and, a C-terminal HECT ubiquitin ligase catalytic domain. It plays critical role in the regulation of a number of membrane receptors, endocytic machinery components and the tumor suppressor PTEN. [provided by RefSeq, Jul 2016]
Synonyms	NEDD4-1; RPF1
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Endocytosis, Ubiquitin mediated proteolysis

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