Neuroserpin (SERPINI1) Mouse Monoclonal Antibody [Clone ID: OTI1A5]

Specifications

Product Data
Clone Name	OTI1A5
Applications	WB
Recommend Dilution	WB 1:2000
Reactivity	Human, Mouse, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	Human recombinant protein fragment corresponding to amino acids 17-410 of human SERPINI1 (NP_005016) produced in E.coli.
Isotype	IgG1
Formulation	PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Concentration	1 mg/ml
Purification	Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	serpin family I member 1
Database Link	NP_005016 Entrez Gene 20713 MouseEntrez Gene 116459 RatEntrez Gene 5274 Human UniProt ID Q99574
Background	This gene encodes a member of the serpin superfamily of serine proteinase inhibitors. The protein is primarily secreted by axons in the brain, and preferentially reacts with and inhibits tissue-type plasminogen activator. It is thought to play a role in the regulation of axonal growth and the development of synaptic plasticity. Mutations in this gene result in familial encephalopathy with neuroserpin inclusion bodies (FENIB), which is a dominantly inherited form of familial encephalopathy and epilepsy characterized by the accumulation of mutant neuroserpin polymers. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]
Synonyms	HNS-S1; HNS-S2; neuroserpin; PI12
Reference Data
Protein Families	Druggable Genome, Secreted Protein

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