NIRF (UHRF2) Mouse Monoclonal Antibody (HRP conjugated) [Clone ID: OTI4E10]

Specifications

Product Data
Clone Name	OTI4E10
Applications	WB
Recommend Dilution	WB 1:500~2000
Reactivity	Human, Mouse, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	Human recombinant protein fragment corresponding to amino acids 1-288 of human UHRF2(NP_690856) produced in E.coli.
Isotype	IgG1
Formulation	PBS (pH 7.3) containing 1% BSA, 50% glycerol.
Concentration	0.5 mg/ml
Purification	Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation	HRP
Storage Condition	Store at -20°C as received.
Predicted Protein Size	89.8 kDa
Gene Name	ubiquitin like with PHD and ring finger domains 2
Database Link	NP_690856 Entrez Gene 109113 MouseEntrez Gene 309331 RatEntrez Gene 115426 Human UniProt ID Q96PU4
Background	This gene encodes a nuclear protein which is involved in cell-cycle regulation. The encoded protein is a ubiquitin-ligase capable of ubiquinating PCNP (PEST-containing nuclear protein), and together they may play a role in tumorigenesis. The encoded protein contains an NIRF_N domain, a PHD finger, a set- and ring-associated (SRA) domain, and a RING finger domain and several of these domains have been shown to be essential for the regulation of cell proliferation. This protein may also have a role in intranuclear degradation of polyglutamine aggregates. Alternative splicing results in multiple transcript variants some of which are non-protein coding. [provided by RefSeq, Feb 2012]
Synonyms	NIRF; RNF107; TDRD23; URF2
Reference Data
Protein Families	Druggable Genome, Transcription Factors

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