Cryptochrome I (CRY1) Mouse Monoclonal Antibody (Biotin conjugated) [Clone ID: OTI2C10]

Specifications

Product Data
Clone Name	OTI2C10
Applications	WB
Recommend Dilution	WB 1:2000
Reactivity	Human, Mouse, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	Human recombinant protein fragment corresponding to amino acids 502-584 of human CRY1(NP_004066) produced in E.coli.
Isotype	IgG2b
Formulation	PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Concentration	0.5 mg/ml
Purification	Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation	Biotin
Storage Condition	Store at -20°C as received.
Predicted Protein Size	66.2 kDa
Gene Name	cryptochrome circadian clock 1
Database Link	NP_004066 Entrez Gene 12952 MouseEntrez Gene 299691 RatEntrez Gene 1407 Human UniProt ID Q16526
Background	This gene encodes a flavin adenine dinucleotide-binding protein that is a key component of the circadian core oscillator complex, which regulates the circadian clock. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene have been associated with altered sleep patterns. The encoded protein is widely conserved across plants and animals. Loss of the related gene in mouse results in a shortened circadian cycle in complete darkness. [provided by RefSeq, Jan 2014]
Synonyms	PHLL1
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Circadian rhythm - mammal

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