RRBP1 Mouse Monoclonal Antibody [Clone ID: OTI3F1]

Specifications

Product Data
Clone Name	OTI3F1
Applications	IHC, WB
Recommend Dilution	WB 1:2000, IHC 1:1000
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Human recombinant protein fragment corresponding to amino acids 484-590 of human RRBP1(NP_001036041) produced in E.coli.
Isotype	IgG1
Formulation	PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Concentration	1 mg/ml
Purification	Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	108.5 kDa
Gene Name	ribosome binding protein 1
Database Link	NP_001036041 Entrez Gene 6238 Human UniProt ID Q9P2E9
Background	This gene encodes a ribosome-binding protein of the endoplasmic reticulum (ER) membrane. Studies suggest that this gene plays a role in ER proliferation, secretory pathways and secretory cell differentiation, and mediation of ER-microtubule interactions. Alternative splicing has been observed and protein isoforms are characterized by regions of N-terminal decapeptide and C-terminal heptad repeats. Splicing of the tandem repeats results in variations in ribosome-binding affinity and secretory function. The full-length nature of variants which differ in repeat length has not been determined. Pseudogenes of this gene have been identified on chromosomes 3 and 7, and RRBP1 has been excluded as a candidate gene in the cause of Alagille syndrome, the result of a mutation in a nearby gene on chromosome 20p12. [provided by RefSeq, Apr 2012]
Synonyms	ES/130; ES130; hES; p180; RRp
Reference Data
Protein Families	Druggable Genome, Transmembrane

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