ROR1 Mouse Monoclonal Antibody [Clone ID: OTI3F8]

Specifications

Product Data
Clone Name	OTI3F8
Applications	IHC, WB
Recommend Dilution	WB 1:500, IHC 1:2000
Reactivity	Human,Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	Full length human recombinant protein of human ROR1 (NP_005003) produced in HEK293T cell.
Isotype	IgG1
Formulation	PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Concentration	1 mg/ml
Purification	Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation	Unconjugated
Storage Condition	Shipped at -20°C or with ice packs, Upon delivery store at -20°C. Dilute in PBS(pH7.3) if necessary. Stable for 12 months from date of receipt. Avoid repeated freeze-thaws.
Predicted Protein Size	104.1 kDa
Gene Name	receptor tyrosine kinase-like orphan receptor 1
Database Link	NP_005003 Entrez Gene 362550 RatEntrez Gene 4919 Human UniProt ID Q01973
Background	This gene encodes a receptor tyrosine kinase-like orphan receptor that modulates neurite growth in the central nervous system. The encoded protein is a glycosylated type I membrane protein that belongs to the ROR subfamily of cell surface receptors. It is a pseudokinase that lacks catalytic activity and may interact with the non-canonical Wnt signalling pathway. This gene is highly expressed during early embryonic development but expressed at very low levels in adult tissues. Increased expression of this gene is associated with B-cell chronic lymphocytic leukaemia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2012]
Synonyms	dJ537F10.1; NTRKR1
Note	WB application: Only overexpression results are guaranteed, not endogenous
Reference Data
Protein Families	Druggable Genome, Protein Kinase, Transmembrane

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