Cystatin C (CST3) Mouse Monoclonal Capture Antibody [Clone ID: OTI7B8]

Specifications

Product Data
Clone Name	OTI7B8
Applications	ELISA, LMNX
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Full length recombinant protein
Isotype	IgG1
Formulation	PBS (PH 7.3) containing 50% glycerol and 0.02% sodium azide.
Concentration	0.5mg/ml
Purification	Purified from mouse ascites fluids by affinity chromatography (protein A/G)
Conjugation	Unconjugated
Storage Condition	Shipped at -20°C or with ice packs, Upon delivery store at -20°C. Dilute in PBS(pH7.3) if necessary. Stable for 12 months from date of receipt. Avoid repeated freeze-thaws.
Predicted Protein Size	13.3 kDa
Gene Name	cystatin C
Database Link	NP_000090 Entrez Gene 1471 Human UniProt ID P01034
Background	The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions, where they appear to provide protective functions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes the most abundant extracellular inhibitor of cysteine proteases, which is found in high concentrations in biological fluids and is expressed in virtually all organs of the body. A mutation in this gene has been associated with amyloid angiopathy. Expression of this protein in vascular wall smooth muscle cells is severely reduced in both atherosclerotic and aneurysmal aortic lesions, establishing its role in vascular disease. In addition, this protein has been shown to have an antimicrobial function, inhibiting the replication of herpes simplex virus. Alternative splicing results in multiple transcript variants encoding a single protein
Synonyms	ARMD11; HEL-S-2
Reference Data
Protein Families	Druggable Genome, ES Cell Differentiation/IPS, Transmembrane

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