IKB alpha (NFKBIA) Mouse Monoclonal Antibody [Clone ID: OTI2F5]

Specifications

Product Data
Clone Name	OTI2F5
Applications	IF, IHC, WB
Recommend Dilution	WB 1:4000, IHC 1:150, IF: 1:100
Reactivity	Human, Mouse, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	Full length human recombinant protein of human NFKBIA(NP_065390) produced in HEK293T cell.
Isotype	IgG1
Formulation	PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Concentration	1 mg/ml
Purification	Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	35.4 kDa
Gene Name	NFKB inhibitor alpha
Database Link	NP_065390 Entrez Gene 18035 MouseEntrez Gene 25493 RatEntrez Gene 4792 Human UniProt ID P25963
Background	This gene encodes a member of the NF-kappa-B inhibitor family, which contain multiple ankrin repeat domains. The encoded protein interacts with REL dimers to inhibit NF-kappa-B/REL complexes which are involved in inflammatory responses. The encoded protein moves between the cytoplasm and the nucleus via a nuclear localization signal and CRM1-mediated nuclear export. Mutations in this gene have been found in ectodermal dysplasia anhidrotic with T-cell immunodeficiency autosomal dominant disease. [provided by RefSeq, Aug 2011]
Synonyms	IKBA; MAD-3; NFKBI
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Adipocytokine signaling pathway, Apoptosis, B cell receptor signaling pathway, Chemokine signaling pathway, Chronic myeloid leukemia, Cytosolic DNA-sensing pathway, Epithelial cell signaling in Helicobacter pylori infection, Neurotrophin signaling pathway, NOD-like receptor signaling pathway, Pathways in cancer, Prostate cancer, RIG-I-like receptor signaling pathway, Small cell lung cancer, T cell receptor signaling pathway, Toll-like receptor signaling pathway

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