CD163 Mouse Monoclonal Antibody (HRP conjugated) [Clone ID: OTI2B12]

Specifications

Product Data
Clone Name	OTI2B12
Applications	IF, IHC, LMNX, WB
Recommend Dilution	WB 1:200~4000, IHC 1:150, IF 1:100
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Full length human recombinant protein of human CD163(NP_004235) produced in HEK293T cell.
Isotype	IgG2a
Formulation	PBS (pH 7.3) containing 1% BSA, 50% glycerol.
Concentration	0.5 mg/ml
Purification	Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation	HRP
Storage Condition	Store at -20°C as received.
Predicted Protein Size	125.3 kDa
Gene Name	CD163 molecule
Database Link	NP_004235 Entrez Gene 9332 Human UniProt ID Q86VB7
Background	The protein encoded by this gene is a member of the scavenger receptor cysteine-rich (SRCR) superfamily, and is exclusively expressed in monocytes and macrophages. It functions as an acute phase-regulated receptor involved in the clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages, and may thereby protect tissues from free hemoglobin-mediated oxidative damage. This protein may also function as an innate immune sensor for bacteria and inducer of local inflammation. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]
Synonyms	M130; MM130; SCARI1
Reference Data
Protein Families	Druggable Genome, Secreted Protein, Transmembrane

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