SAE1 Mouse Monoclonal Antibody (Biotin conjugated) [Clone ID: OTI1G8]

Specifications

Product Data
Clone Name	OTI1G8
Applications	IF, IHC, WB
Recommend Dilution	WB 1:4000, IHC 1:150, IF 1:100
Reactivity	Human, Mouse, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	Full length human recombinant protein of human SAE1(NP_005491) produced in HEK293T cell.
Isotype	IgG2b
Formulation	PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Concentration	0.5 mg/ml
Purification	Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation	Biotin
Storage Condition	Store at -20°C as received.
Predicted Protein Size	38.3 kDa
Gene Name	SUMO1 activating enzyme subunit 1
Database Link	NP_005491 Entrez Gene 56459 MouseEntrez Gene 308384 RatEntrez Gene 10055 Human UniProt ID Q9UBE0
Background	Posttranslational modification of proteins by the addition of the small protein SUMO (see SUMO1; MIM 601912), or sumoylation, regulates protein structure and intracellular localization. SAE1 and UBA2 (MIM 613295) form a heterodimer that functions as a SUMO-activating enzyme for the sumoylation of proteins (Okuma et al., 1999 [PubMed 9920803]). [supplied by OMIM, Mar 2010]
Synonyms	AOS1; HSPC140; SUA1; UBLE1A
Reference Data
Protein Pathways	Ubiquitin mediated proteolysis

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