PTPN7 Mouse Monoclonal Antibody (Biotin conjugated) [Clone ID: OTI3G2]

Specifications

Product Data
Clone Name	OTI3G2
Applications	IF, IHC, WB
Recommend Dilution	WB 1:2000, IHC 1:150, IF 1:100
Reactivity	Human, Mouse, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	Full length human recombinant protein of human PTPN7(NP_542155) produced in HEK293T cell.
Isotype	IgG1
Formulation	PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Concentration	0.5 mg/ml
Purification	Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation	Biotin
Storage Condition	Store at -20°C as received.
Predicted Protein Size	44.8 kDa
Gene Name	protein tyrosine phosphatase non-receptor type 7
Database Link	NP_542155 Entrez Gene 246781 RatEntrez Gene 320139 MouseEntrez Gene 5778 Human UniProt ID P35236
Background	The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This gene is preferentially expressed in a variety of hematopoietic cells, and is an early response gene in lymphokine stimulated cells. The non-catalytic N-terminus of this PTP can interact with MAP kinases and suppress the MAP kinase activities. This PTP was shown to be involved in the regulation of T cell antigen receptor (TCR) signaling, which was thought to function through dephosphorylating the molecules related to MAP kinase pathway. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq]
Synonyms	BPTP-4; HEPTP; LC-PTP; LPTP; PTPNI
Reference Data
Protein Families	Druggable Genome, Phosphatase
Protein Pathways	MAPK signaling pathway

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