Aminoacylase 1 (ACY1) Mouse Monoclonal Antibody [Clone ID: OTI1B12]

Specifications

Product Data
Clone Name	OTI1B12
Applications	FC, IHC, WB
Recommend Dilution	WB 1:200~500, IHC 1:150, FLOW 1:100
Reactivity	Human, Dog, Rat, Mouse
Host	Mouse
Clonality	Monoclonal
Immunogen	Full length human recombinant protein of human ACY1(NP_000657) produced in HEk293 cell.
Isotype	IgG1
Formulation	PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Concentration	0.28 mg/ml
Purification	Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	45.7 kDa
Gene Name	aminoacylase 1
Database Link	NP_000657 Entrez Gene 109652 MouseEntrez Gene 300981 RatEntrez Gene 476602 DogEntrez Gene 95 Human UniProt ID Q03154
Background	This gene encodes a cytosolic, homodimeric, zinc-binding enzyme that catalyzes the hydrolysis of acylated L-amino acids to L-amino acids and an acyl group, and has been postulated to function in the catabolism and salvage of acylated amino acids. This gene is located on chromosome 3p21.1, a region reduced to homozygosity in small-cell lung cancer (SCLC), and its expression has been reported to be reduced or undetectable in SCLC cell lines and tumors. The amino acid sequence of human aminoacylase-1 is highly homologous to the porcine counterpart, and this enzyme is the first member of a new family of zinc-binding enzymes. Mutations in this gene cause aminoacylase-1 deficiency, a metabolic disorder characterized by central nervous system defects and increased urinary excretion of N-acetylated amino acids. Alternative splicing of this gene results in multiple transcript variants. Read-through transcription also exists between this gene and the upstream ABHD14A (abhydrolase domain containing 14A) gene, as represented in GeneID:100526760. A related pseudogene has been identified on chromosome 18. [provided by RefSeq]
Synonyms	ACY-1; ACY1D; HEL-S-5
Reference Data
Protein Families	Protease
Protein Pathways	Arginine and proline metabolism, Metabolic pathways

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