STAT4 Mouse Monoclonal Antibody (Biotin conjugated) [Clone ID: OTI2F3]

Specifications

Product Data
Clone Name	OTI2F3
Applications	FC, IF, IHC, WB
Recommend Dilution	WB 1:2000, IHC 1:150, IF 1:100, FLOW 1:100
Reactivity	Human, Mouse, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	Full length human recombinant protein of human STAT4(NP_003142) produced in HEK293T cell.
Isotype	IgG1
Formulation	PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Concentration	0.5 mg/ml
Purification	Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation	Biotin
Storage Condition	Store at -20°C as received.
Predicted Protein Size	85.8 kDa
Gene Name	signal transducer and activator of transcription 4
Database Link	NP_003142 Entrez Gene 20849 MouseEntrez Gene 367264 RatEntrez Gene 6775 Human UniProt ID Q14765
Background	The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is essential for mediating responses to IL12 in lymphocytes, and regulating the differentiation of T helper cells. Mutations in this gene may be associated with systemic lupus erythematosus and rheumatoid arthritis. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Aug
Synonyms	SLEB11
Reference Data
Protein Families	Druggable Genome, Transcription Factors
Protein Pathways	Jak-STAT signaling pathway

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